HitPredict

Interactor 1: KMT2A (Q03164)
Histone-lysine N-methyltransferase 2A (Lysine N-methyltransferase 2A) (EC 2.1.1.364) (ALL-1) (CXXC-type zinc finger protein 7) (Cysteine methyltransferase KMT2A) (EC 2.1.1.-) (Myeloid/lymphoid or mixed-lineage leukemia) (Myeloid/lymphoid or mixed-lineage leukemia protein 1) (Trithorax-like protein) (Zinc finger protein HRX) [Cleaved into: MLL cleavage product N320 (N-terminal cleavage product of 320 kDa) (p320); MLL cleavage product C180 (C-terminal cleavage product of 180 kDa) (p180)]
Gene: KMT2A

Interactor 2: SRSF4 (Q08170)
Serine/arginine-rich splicing factor 4 (Pre-mRNA-splicing factor SRP75) (SRP001LB) (Splicing factor, arginine/serine-rich 4)
Gene: SRSF4

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.691

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	PHD~RRM_1
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 3969 Hs			1 494
+	Hs
		975240 KMT2A_HUMAN (1-3969): 0: 3187: 100.00		SRSF6_HUMAN (1-180): 4.52e-52: 181: 78.50
+	Hs
		975239 KMT2A_HUMAN (1-3969): 0: 3187: 100.00		SRSF5_HUMAN (3-256): 1.26e-49: 172: 53.85
+	Hs
		992789 EZH2_HUMAN (3450-3951): 9.4e-105: 357: 18.54		SRSF1_HUMAN (3-166): 2.36e-57: 192: 41.42
+	Hs
		1028558 EZH2_HUMAN (3450-3951): 9.4e-105: 357: 18.54		SRSF9_HUMAN (3-216): 2.36e-52: 178: 36.53
+	Hs
		1028670 EZH2_HUMAN (3450-3951): 9.4e-105: 357: 18.54		SRSF5_HUMAN (3-256): 1.26e-49: 172: 53.85
+	Hs
		516536 EZH2_HUMAN (3450-3951): 9.4e-105: 357: 18.54		PABP1_HUMAN (1-189): 4.04e-31: 128: 19.50
+	Hs
		1029077 SETD2_HUMAN (3398-3968): 1.14e-75: 285: 16.61		SRSF6_HUMAN (1-180): 4.52e-52: 181: 78.50
+	Hs
		1031345 EZH2_HUMAN (3450-3951): 9.4e-105: 357: 18.54		PABP4_HUMAN (100-185): 3.19e-11: 67.7: 19.78
+	Hs
		963528 EZH2_HUMAN (3450-3951): 9.4e-105: 357: 18.54		TIAR_HUMAN (96-188): 2.66e-10: 63.8: 16.67
+	Hs
		331803 NSD2_HUMAN (3752-3968): 7.27e-60: 231: 27.23		SRSF6_HUMAN (1-180): 4.52e-52: 181: 78.50
+	Hs
		331795 NSD2_HUMAN (3752-3968): 7.27e-60: 231: 27.23		SRSF4_HUMAN (1-468): 4.56e-48: 174: 100.00
+	Hs
		331802 NSD2_HUMAN (3752-3968): 7.27e-60: 231: 27.23		SRSF5_HUMAN (3-256): 1.26e-49: 172: 53.85
+	Sc
		633962 SET2_YEAST (3811-3968): 1.56e-56: 214: 29.56		GBP2_YEAST (4-201): 2.69e-25: 109: 20.19
+	Hs
		331871 NSD2_HUMAN (3752-3968): 7.27e-60: 231: 27.23		RBM4B_HUMAN (3-104): 4.68e-11: 66.1: 23.08
+	Pf
		87011 SET1_PLAF7 (1476-1625): 2.27e-46: 188: 28.76		Q8I3T5_PLAF7 (3-248): 2.75e-23: 101: 27.94
+	Sc
		376833 SET2_YEAST (3811-3968): 1.56e-56: 214: 29.56		PABP_YEAST (72-188): 2.61e-10: 64.6: 14.75
+	Hs
		1029050 MINT_HUMAN (418-1102): 7.18e-09: 64.7: 11.18		SRSF6_HUMAN (1-180): 4.52e-52: 181: 78.50
+	Hs
		516595 KMT2C_HUMAN (384-1407): 6.81e-11: 71.4: 10.23		PABP1_HUMAN (1-189): 4.04e-31: 128: 19.50