HitPredict

Interactor 1: KMT2A (Q03164)
Histone-lysine N-methyltransferase 2A (Lysine N-methyltransferase 2A) (EC 2.1.1.364) (ALL-1) (CXXC-type zinc finger protein 7) (Cysteine methyltransferase KMT2A) (EC 2.1.1.-) (Myeloid/lymphoid or mixed-lineage leukemia) (Myeloid/lymphoid or mixed-lineage leukemia protein 1) (Trithorax-like protein) (Zinc finger protein HRX) [Cleaved into: MLL cleavage product N320 (N-terminal cleavage product of 320 kDa) (p320); MLL cleavage product C180 (C-terminal cleavage product of 180 kDa) (p180)]
Gene: KMT2A

Interactor 2: RBBP4 (Q09028)
Histone-binding protein RBBP4 (Chromatin assembly factor 1 subunit C) (CAF-1 subunit C) (Chromatin assembly factor I p48 subunit) (CAF-I 48 kDa subunit) (CAF-I p48) (Nucleosome-remodeling factor subunit RBAP48) (Retinoblastoma-binding protein 4) (RBBP-4) (Retinoblastoma-binding protein p48)
Gene: RBBP4

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	12453419
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	SET~WD40
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0045893 - positive regulation of DNA-templated transcription
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 3969 Hs			1 425
+	Hs
		975266 KMT2A_HUMAN (1-3969): 0: 3187: 100.00		RBBP7_HUMAN (1-425): 3.63e-115: 345: 89.20
+	Hs
		903149 KMT2A_HUMAN (1-3969): 0: 3187: 100.00		WDR5_HUMAN (267-425): 7.48e-35: 133: 25.61
+	Hs
		975315 KMT2A_HUMAN (1-3969): 0: 3187: 100.00		GRWD1_HUMAN (263-425): 3.54e-26: 111: 23.56
+	Mm
		936646 EZH1_MOUSE (3468-3951): 9.84e-108: 366: 18.49		RBBP4_MOUSE (1-425): 4.3e-124: 367: 100.00
+	Hs
		997839 EZH1_HUMAN (3468-3951): 2.87e-107: 364: 18.29		RBBP4_HUMAN (1-425): 4.3e-124: 367: 100.00
+	Mm
		1141929 EZH2_MOUSE (3450-3951): 3.64e-105: 358: 18.54		RBBP4_MOUSE (1-425): 4.3e-124: 367: 100.00
+	Hs
		997735 EZH2_HUMAN (3450-3951): 9.4e-105: 357: 18.54		RBBP4_HUMAN (1-425): 4.3e-124: 367: 100.00
+	Mm
		1141935 Q6AXH7_MOUSE (3450-3951): 9.61e-104: 354: 18.18		RBBP4_MOUSE (1-425): 4.3e-124: 367: 100.00
+	Hs
		1083337 EZH1_HUMAN (3468-3951): 2.87e-107: 364: 18.29		RBBP7_HUMAN (1-425): 3.63e-115: 345: 89.20
+	Mm
		936647 EZH1_MOUSE (3468-3951): 9.84e-108: 366: 18.49		RBBP7_MOUSE (1-425): 1.21e-114: 343: 89.20
+	Hs
		1079986 EZH2_HUMAN (3450-3951): 9.4e-105: 357: 18.54		RBBP7_HUMAN (1-425): 3.63e-115: 345: 89.20
+	Mm
		1141957 EZH2_MOUSE (3450-3951): 3.64e-105: 358: 18.54		RBBP7_MOUSE (1-425): 1.21e-114: 343: 89.20
+	Mm
		1141960 Q6AXH7_MOUSE (3450-3951): 9.61e-104: 354: 18.18		RBBP7_MOUSE (1-425): 1.21e-114: 343: 89.20
+	Hs
		267764 EZH2_HUMAN (3450-3951): 9.4e-105: 357: 18.54		TAF5L_HUMAN (26-422): 3e-74: 244: 22.20
+	Hs
		903604 KMT2B_HUMAN (3163-3969): 3.56e-127: 454: 36.71		WDR5_HUMAN (267-425): 7.48e-35: 133: 25.61
+	At
		187006 CLF_ARATH (3430-3963): 4.23e-85: 304: 19.76		MSI4_ARATH (5-415): 2.7e-81: 260: 31.11
+	At
		1319861 ATX1_ARATH (3430-3969): 9.67e-101: 354: 21.12		WDR5A_ARATH (267-425): 1.04e-32: 127: 22.02
+	Dm
		785628 EZ_DROME (3447-3950): 2.33e-95: 330: 16.11		CAF1_DROME (226-419): 3.68e-29: 119: 18.36
+	Dm
		1129076 SET1_DROME (3423-3969): 3.44e-81: 301: 21.22		WDS_DROME (267-425): 9.83e-34: 131: 26.22
+	At
		186924 CLF_ARATH (3430-3963): 4.23e-85: 304: 19.76		MSI1_ARATH (2-210): 3.43e-31: 125: 13.22