HitPredict

Interactor 1: KMT2A (Q03164)
Histone-lysine N-methyltransferase 2A (Lysine N-methyltransferase 2A) (EC 2.1.1.364) (ALL-1) (CXXC-type zinc finger protein 7) (Cysteine methyltransferase KMT2A) (EC 2.1.1.-) (Myeloid/lymphoid or mixed-lineage leukemia) (Myeloid/lymphoid or mixed-lineage leukemia protein 1) (Trithorax-like protein) (Zinc finger protein HRX) [Cleaved into: MLL cleavage product N320 (N-terminal cleavage product of 320 kDa) (p320); MLL cleavage product C180 (C-terminal cleavage product of 180 kDa) (p180)]
Gene: KMT2A

Interactor 2: RBBP5 (Q15291)
Retinoblastoma-binding protein 5 (RBBP-5) (Retinoblastoma-binding protein RBQ-3)
Gene: RBBP5

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.97	1.00	0.986

Property	Details
Experiments	15199122, 31076518, 31400120, 24981860, 33961781, 23508102, 37689310, 15960975, 23870121, 27563068, 28182322, 31685992, 31544921, 22665483, 24081332
Identification Methods	affinity chromatography technology, pull down, proximity labelling technology, biochemical, anti tag coimmunoprecipitation, anti bait coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	SET~WD40
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0035097 - histone methyltransferase complex GO:0045815 - transcription initiation-coupled chromatin remodeling GO:0071339 - MLL1 complex
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 3969 Hs			1 538
+	Mm
		876680 KMT2A_MOUSE (1-3969): 0: 3189: 90.32		RBBP5_MOUSE (1-538): 9.56e-137: 408: 99.07
+	Hs
		975304 KMT2A_HUMAN (1-3969): 0: 3187: 100.00		SNR40_HUMAN (229-467): 1.49e-19: 92: 9.59
+	Hs
		975303 KMT2A_HUMAN (1-3969): 0: 3187: 100.00		FBXW7_HUMAN (279-521): 2.8e-16: 83.9: 10.56
+	Hs
		903149 KMT2A_HUMAN (1-3969): 0: 3187: 100.00		WDR5_HUMAN (282-429): 2.1e-09: 61.2: 11.41
+	Hs
		1070808 KMT2B_HUMAN (3163-3969): 3.56e-127: 454: 36.71		RBBP5_HUMAN (1-538): 2.69e-137: 410: 100.00
+	Hs
		1070809 SET1B_HUMAN (3529-3969): 1.64e-66: 254: 27.12		RBBP5_HUMAN (1-538): 2.69e-137: 410: 100.00
+	Dm
		1129085 SET1_DROME (3423-3969): 3.44e-81: 301: 21.22		RBBP5_DROME (1-494): 3.54e-103: 320: 65.79
+	Sp
		194056 SET1_SCHPO (3434-3969): 1.62e-77: 281: 22.46		SWD1_SCHPO (1-392): 1.06e-88: 280: 32.68
+	Hs
		1288387 KMT2B_HUMAN (3163-3969): 3.56e-127: 454: 36.71		SNR40_HUMAN (229-467): 1.49e-19: 92: 9.59
+	Hs
		203735 SUV91_HUMAN (3630-3968): 1.07e-83: 284: 18.97		DAW1_HUMAN (54-395): 7.21e-75: 244: 15.12
+	Sc
		755771 SET1_YEAST (3466-3969): 6.89e-73: 270: 21.67		SWD1_YEAST (1-356): 1.48e-77: 252: 30.08
+	Hs
		903604 KMT2B_HUMAN (3163-3969): 3.56e-127: 454: 36.71		WDR5_HUMAN (282-429): 2.1e-09: 61.2: 11.41
+	At
		1319861 ATX1_ARATH (3430-3969): 9.67e-101: 354: 21.12		WDR5A_ARATH (182-434): 2.41e-37: 142: 16.93
+	Hs
		1080207 EZH2_HUMAN (3450-3951): 9.4e-105: 357: 18.54		FBXW7_HUMAN (279-521): 2.8e-16: 83.9: 10.56
+	Hs
		1080166 EZH2_HUMAN (3450-3951): 9.4e-105: 357: 18.54		PHIP_HUMAN (227-374): 6.69e-15: 80.4: 13.91
+	Hs
		1317584 SETD2_HUMAN (3398-3968): 1.14e-75: 285: 16.61		NLE1_HUMAN (2-135): 8.57e-34: 135: 18.38
+	Dm
		1129076 SET1_DROME (3423-3969): 3.44e-81: 301: 21.22		WDS_DROME (250-438): 1.02e-21: 98.5: 10.82
+	Hs
		1288291 SETD2_HUMAN (3398-3968): 1.14e-75: 285: 16.61		SNR40_HUMAN (229-467): 1.49e-19: 92: 9.59
+	Hs
		331862 NSD2_HUMAN (3752-3968): 7.27e-60: 231: 27.23		SNR40_HUMAN (229-467): 1.49e-19: 92: 9.59
+	Hs
		903609 SET1B_HUMAN (3529-3969): 1.64e-66: 254: 27.12		WDR5_HUMAN (282-429): 2.1e-09: 61.2: 11.41