HitPredict

Interactor 1: KMT2A (Q03164)
Histone-lysine N-methyltransferase 2A (Lysine N-methyltransferase 2A) (EC 2.1.1.364) (ALL-1) (CXXC-type zinc finger protein 7) (Cysteine methyltransferase KMT2A) (EC 2.1.1.-) (Myeloid/lymphoid or mixed-lineage leukemia) (Myeloid/lymphoid or mixed-lineage leukemia protein 1) (Trithorax-like protein) (Zinc finger protein HRX) [Cleaved into: MLL cleavage product N320 (N-terminal cleavage product of 320 kDa) (p320); MLL cleavage product C180 (C-terminal cleavage product of 180 kDa) (p180)]
Gene: KMT2A

Interactor 2: H31T (Q16695)
Histone H3.1t (H3/t) (H3t) (H3/g) (Histone H3.4)
Gene: H3-4

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.87	1.00	0.935

Property	Details
Experiments	34349018, 21135039, 26324722, 28182322, 21124902, 21030982
Identification Methods	cross-linking study, unspecified method, enzymatic study
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	Histone~SET
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 3969 Hs			1 136
+	Hs
		934681 KMT2A_HUMAN (1-3969): 0: 3187: 100.00		H31_HUMAN (1-136): 6.88e-62: 187: 97.06
+	Hs
		952284 KMT2A_HUMAN (1-3969): 0: 3187: 100.00		H33_HUMAN (1-136): 4.53e-61: 185: 93.38
+	Hs
		975278 KMT2A_HUMAN (1-3969): 0: 3187: 100.00		H32_HUMAN (1-136): 1.34e-60: 184: 96.32
+	Hs
		828202 KMT2A_HUMAN (1-3969): 0: 3187: 100.00		CENPA_HUMAN (9-133): 3.54e-44: 142: 49.24
+	Mm
		139069 KMT2B_MOUSE (3163-3969): 3.93e-143: 506: 38.40		H33_MOUSE (1-136): 4.53e-61: 185: 93.38
+	Hs
		935368 KMT2B_HUMAN (3163-3969): 3.56e-127: 454: 36.71		H31_HUMAN (1-136): 6.88e-62: 187: 97.06
+	Hs
		952698 KMT2B_HUMAN (3163-3969): 3.56e-127: 454: 36.71		H33_HUMAN (1-136): 4.53e-61: 185: 93.38
+	Hs
		1174689 KMT2B_HUMAN (3163-3969): 3.56e-127: 454: 36.71		H32_HUMAN (1-136): 1.34e-60: 184: 96.32
+	Hs
		828421 KMT2B_HUMAN (3163-3969): 3.56e-127: 454: 36.71		CENPA_HUMAN (9-133): 3.54e-44: 142: 49.24
+	Hs
		934804 EZH2_HUMAN (3450-3951): 9.4e-105: 357: 18.54		H31_HUMAN (1-136): 6.88e-62: 187: 97.06
+	Hs
		1079993 EZH2_HUMAN (3450-3951): 9.4e-105: 357: 18.54		H31T_HUMAN (1-136): 2.65e-61: 186: 100.00
+	Mm
		952747 EZH2_MOUSE (3450-3951): 3.64e-105: 358: 18.54		H33_MOUSE (1-136): 4.53e-61: 185: 93.38
+	Hs
		952363 EZH2_HUMAN (3450-3951): 9.4e-105: 357: 18.54		H33_HUMAN (1-136): 4.53e-61: 185: 93.38
+	Mm
		952754 Q6AXH7_MOUSE (3450-3951): 9.61e-104: 354: 18.18		H33_MOUSE (1-136): 4.53e-61: 185: 93.38
+	Hs
		1080038 EZH2_HUMAN (3450-3951): 9.4e-105: 357: 18.54		H3C_HUMAN (1-136): 2.16e-58: 178: 90.44
+	Dm
		356072 EZ_DROME (3447-3950): 2.33e-95: 330: 16.11		H3_DROME (1-136): 1.34e-60: 184: 96.32
+	Dm
		356073 SUV39_DROME (3413-3968): 4.15e-91: 314: 13.60		H3_DROME (1-136): 1.34e-60: 184: 96.32
+	Dm
		356084 SET1_DROME (3423-3969): 3.44e-81: 301: 21.22		H3_DROME (1-136): 1.34e-60: 184: 96.32
+	Hs
		935204 SETD2_HUMAN (3398-3968): 1.14e-75: 285: 16.61		H31_HUMAN (1-136): 6.88e-62: 187: 97.06
+	Hs
		1086306 SETD2_HUMAN (3398-3968): 1.14e-75: 285: 16.61		H31T_HUMAN (1-136): 2.65e-61: 186: 100.00