HitPredict

Interactor 1: KMT2A (Q03164)
Histone-lysine N-methyltransferase 2A (Lysine N-methyltransferase 2A) (EC 2.1.1.364) (ALL-1) (CXXC-type zinc finger protein 7) (Cysteine methyltransferase KMT2A) (EC 2.1.1.-) (Myeloid/lymphoid or mixed-lineage leukemia) (Myeloid/lymphoid or mixed-lineage leukemia protein 1) (Trithorax-like protein) (Zinc finger protein HRX) [Cleaved into: MLL cleavage product N320 (N-terminal cleavage product of 320 kDa) (p320); MLL cleavage product C180 (C-terminal cleavage product of 180 kDa) (p180)]
Gene: KMT2A

Interactor 2: MCRS1 (Q96EZ8)
Microspherule protein 1 (58 kDa microspherule protein) (Cell cycle-regulated factor p78) (INO80 complex subunit J) (MCRS2)
Gene: MCRS1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	24981860
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0036211 - protein modification process GO:0045893 - positive regulation of DNA-templated transcription GO:0045944 - positive regulation of transcription by RNA polymerase II and 1 others more... GO:0071339 - MLL1 complex
Homologous interactions	4

Homologous interactions

Color coding for hit scores

	1 3969 Hs			1 462
+	Hs
		1290784 KMT2B_HUMAN (3163-3969): 3.56e-127: 454: 36.71		MCRS1_HUMAN (1-462): 0: 695: 100.00
+	Hs
		203760 SUV91_HUMAN (3630-3968): 1.07e-83: 284: 18.97		MCRS1_HUMAN (1-462): 0: 695: 100.00
+	Hs
		1290785 SET1B_HUMAN (3529-3969): 1.64e-66: 254: 27.12		MCRS1_HUMAN (1-462): 0: 695: 100.00
+	Hs
		165708 SET1A_HUMAN (3695-3969): 8.18e-56: 218: 34.58		MCRS1_HUMAN (1-462): 0: 695: 100.00