HitPredict

Interactor 1: KMT2A (Q03164)
Histone-lysine N-methyltransferase 2A (Lysine N-methyltransferase 2A) (EC 2.1.1.364) (ALL-1) (CXXC-type zinc finger protein 7) (Cysteine methyltransferase KMT2A) (EC 2.1.1.-) (Myeloid/lymphoid or mixed-lineage leukemia) (Myeloid/lymphoid or mixed-lineage leukemia protein 1) (Trithorax-like protein) (Zinc finger protein HRX) [Cleaved into: MLL cleavage product N320 (N-terminal cleavage product of 320 kDa) (p320); MLL cleavage product C180 (C-terminal cleavage product of 180 kDa) (p180)]
Gene: KMT2A

Interactor 2: GRWD1 (Q9BQ67)
Glutamate-rich WD repeat-containing protein 1
Gene: GRWD1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	34933446
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	SET~WD40
Common GO terms	GO:0003682 - chromatin binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 3969 Hs			1 446
+	Hs
		903149 KMT2A_HUMAN (1-3969): 0: 3187: 100.00		WDR5_HUMAN (248-445): 8.04e-48: 168: 21.72
+	Hs
		975266 KMT2A_HUMAN (1-3969): 0: 3187: 100.00		RBBP7_HUMAN (66-247): 3.57e-20: 94.3: 10.42
+	Hs
		975233 KMT2A_HUMAN (1-3969): 0: 3187: 100.00		RBBP4_HUMAN (62-247): 7.65e-20: 93.1: 10.71
+	Hs
		903604 KMT2B_HUMAN (3163-3969): 3.56e-127: 454: 36.71		WDR5_HUMAN (248-445): 8.04e-48: 168: 21.72
+	At
		187006 CLF_ARATH (3430-3963): 4.23e-85: 304: 19.76		MSI4_ARATH (4-444): 1.59e-66: 222: 19.18
+	At
		1319861 ATX1_ARATH (3430-3969): 9.67e-101: 354: 21.12		WDR5A_ARATH (249-445): 7.37e-45: 160: 18.69
+	Dm
		1129076 SET1_DROME (3423-3969): 3.44e-81: 301: 21.22		WDS_DROME (248-445): 1.19e-46: 166: 21.21
+	Mm
		936647 EZH1_MOUSE (3468-3951): 9.84e-108: 366: 18.49		RBBP7_MOUSE (66-247): 3.22e-20: 94.3: 10.42
+	Mm
		936646 EZH1_MOUSE (3468-3951): 9.84e-108: 366: 18.49		RBBP4_MOUSE (62-247): 7.65e-20: 93.1: 10.71
+	Hs
		1083337 EZH1_HUMAN (3468-3951): 2.87e-107: 364: 18.29		RBBP7_HUMAN (66-247): 3.57e-20: 94.3: 10.42
+	Hs
		997839 EZH1_HUMAN (3468-3951): 2.87e-107: 364: 18.29		RBBP4_HUMAN (62-247): 7.65e-20: 93.1: 10.71
+	Mm
		1141957 EZH2_MOUSE (3450-3951): 3.64e-105: 358: 18.54		RBBP7_MOUSE (66-247): 3.22e-20: 94.3: 10.42
+	Hs
		1079986 EZH2_HUMAN (3450-3951): 9.4e-105: 357: 18.54		RBBP7_HUMAN (66-247): 3.57e-20: 94.3: 10.42
+	Mm
		1141929 EZH2_MOUSE (3450-3951): 3.64e-105: 358: 18.54		RBBP4_MOUSE (62-247): 7.65e-20: 93.1: 10.71
+	Hs
		997735 EZH2_HUMAN (3450-3951): 9.4e-105: 357: 18.54		RBBP4_HUMAN (62-247): 7.65e-20: 93.1: 10.71
+	Mm
		1141960 Q6AXH7_MOUSE (3450-3951): 9.61e-104: 354: 18.18		RBBP7_MOUSE (66-247): 3.22e-20: 94.3: 10.42
+	Mm
		1141935 Q6AXH7_MOUSE (3450-3951): 9.61e-104: 354: 18.18		RBBP4_MOUSE (62-247): 7.65e-20: 93.1: 10.71
+	Dm
		785628 EZ_DROME (3447-3950): 2.33e-95: 330: 16.11		CAF1_DROME (62-247): 5.03e-21: 96.6: 10.71
+	At
		186924 CLF_ARATH (3430-3963): 4.23e-85: 304: 19.76		MSI1_ARATH (307-445): 6.04e-14: 75.4: 16.89
+	Hs
		1317584 SETD2_HUMAN (3398-3968): 1.14e-75: 285: 16.61		NLE1_HUMAN (338-445): 4.67e-18: 88.1: 13.89