HitPredict

Interactor 1: KMT2A (Q03164)
Histone-lysine N-methyltransferase 2A (Lysine N-methyltransferase 2A) (EC 2.1.1.364) (ALL-1) (CXXC-type zinc finger protein 7) (Cysteine methyltransferase KMT2A) (EC 2.1.1.-) (Myeloid/lymphoid or mixed-lineage leukemia) (Myeloid/lymphoid or mixed-lineage leukemia protein 1) (Trithorax-like protein) (Zinc finger protein HRX) [Cleaved into: MLL cleavage product N320 (N-terminal cleavage product of 320 kDa) (p320); MLL cleavage product C180 (C-terminal cleavage product of 180 kDa) (p180)]
Gene: KMT2A

Interactor 2: HCFC2 (Q9Y5Z7)
Host cell factor 2 (HCF-2) (C2 factor)
Gene: HCFC2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.82	0.60	0.702

Property	Details
Experiments	15199122, 28514442, 24981860, 33961781
Identification Methods	biochemical, affinity chromatography technology, anti tag coimmunoprecipitation, anti bait coimmunoprecipitation
Interaction Type	association, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0035097 - histone methyltransferase complex GO:0071339 - MLL1 complex
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 3969 Hs			1 792
+	Hs
		848199 KMT2A_HUMAN (1-3969): 0: 3187: 100.00		HCFC1_HUMAN (513-789): 6.49e-98: 336: 42.81
+	Mm
		876679 KMT2A_MOUSE (1-3969): 0: 3189: 90.32		HCFC1_MOUSE (566-789): 1.8e-97: 334: 51.09
+	Hs
		1357298 KMT2B_HUMAN (3163-3969): 3.56e-127: 454: 36.71		HCFC2_HUMAN (1-792): 0: 767: 100.00
+	Hs
		1357739 SET1B_HUMAN (3529-3969): 1.64e-66: 254: 27.12		HCFC2_HUMAN (1-792): 0: 767: 100.00
+	Hs
		165746 SET1A_HUMAN (3695-3969): 8.18e-56: 218: 34.58		HCFC2_HUMAN (1-792): 0: 767: 100.00
+	Hs
		1243854 KMT2C_HUMAN (384-1407): 6.81e-11: 71.4: 10.23		HCFC2_HUMAN (1-792): 0: 767: 100.00
+	Hs
		152704 KMT2D_HUMAN (11-1393): 8.17e-09: 64.4: 10.47		HCFC2_HUMAN (1-792): 0: 767: 100.00
+	Hs
		848317 KMT2B_HUMAN (3163-3969): 3.56e-127: 454: 36.71		HCFC1_HUMAN (513-789): 6.49e-98: 336: 42.81
+	Hs
		848225 EZH2_HUMAN (3450-3951): 9.4e-105: 357: 18.54		HCFC1_HUMAN (513-789): 6.49e-98: 336: 42.81
+	Dm
		1129077 SET1_DROME (3423-3969): 3.44e-81: 301: 21.22		HCF_DROME (416-784): 6.61e-85: 297: 30.69
+	Hs
		848319 SET1B_HUMAN (3529-3969): 1.64e-66: 254: 27.12		HCFC1_HUMAN (513-789): 6.49e-98: 336: 42.81
+	Dm
		1215702 TRR_DROME (3623-3969): 9.32e-71: 268: 31.59		HCF_DROME (416-784): 6.61e-85: 297: 30.69
+	Hs
		165649 SET1A_HUMAN (3695-3969): 8.18e-56: 218: 34.58		HCFC1_HUMAN (513-789): 6.49e-98: 336: 42.81
+	Hs
		1080502 EZH2_HUMAN (3450-3951): 9.4e-105: 357: 18.54		KLDC2_HUMAN (5-308): 2.57e-40: 155: 18.79
+	Hs
		203776 SUV91_HUMAN (3630-3968): 1.07e-83: 284: 18.97		KLDC3_HUMAN (58-426): 1.21e-60: 211: 19.95
+	Dm
		785649 EZ_DROME (3447-3950): 2.33e-95: 330: 16.11		Q9W3D5_DROME (188-355): 3e-28: 120: 20.65
+	Hs
		848256 KMT2C_HUMAN (384-1407): 6.81e-11: 71.4: 10.23		HCFC1_HUMAN (513-789): 6.49e-98: 336: 42.81
+	Hs
		152616 KMT2D_HUMAN (11-1393): 8.17e-09: 64.4: 10.47		HCFC1_HUMAN (513-789): 6.49e-98: 336: 42.81
+	Zm
		35425 A0A1D6LLI6_MAIZE (3438-3962): 1.83e-76: 279: 15.16		A0A1D6PPA8_MAIZE (1-191): 1.45e-20: 98.8: 19.29
+	Hs
		203817 SUV91_HUMAN (3630-3968): 1.07e-83: 284: 18.97		KLH20_HUMAN (353-486): 7.9e-11: 67.6: 5.97