HitPredict

Interactor 1: RAC1 (Q03206)
Ras-related protein ced-10 (CErac1) (Cell death protein 10) (Cell-corpse engulfment protein ced-10) (Ras-related protein rac-1)
Gene: ced-10

Interactor 2: Q7KPP4 (Q7KPP4)
CRAL-TRIO domain-containing protein (Guanine nucleotide exchange factor UNC-73B)
Gene: unc-73

Species: Caenorhabditis elegans

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.62	1.00	0.793

Property	Details
Experiments	12972602, 12297102
Identification Methods	enzymatic study, two hybrid
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	Ras~RhoGEF
Common GO terms	GO:0001764 - neuron migration GO:0002119 - nematode larval development GO:0016477 - cell migration GO:0032228 - regulation of synaptic transmission, GABAergic GO:0043652 - engulfment of apoptotic cell
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 191 Ce			1 1638
+	Hs
		50555 RHOQ_HUMAN (4-187): 2.01e-82: 244: 60.87		PKHG3_HUMAN (1165-1566): 9.89e-89: 318: 21.03
+	Hs
		50580 RAC1_HUMAN (1-191): 2.82e-82: 243: 82.81		PKHG3_HUMAN (1165-1566): 9.89e-89: 318: 21.03
+	Ce
		136793 RAC1_CAEEL (1-191): 1.92e-84: 249: 100.00		UNC89_CAEEL (1171-1549): 1.04e-55: 217: 18.46
+	Hs
		855782 RAC1_HUMAN (1-191): 2.82e-82: 243: 82.81		VAV2_HUMAN (1134-1634): 3.62e-52: 201: 13.04
+	Hs
		925330 RAC1_HUMAN (1-191): 2.82e-82: 243: 82.81		PKHG4_HUMAN (17-497): 7.73e-48: 189: 14.34
+	Hs
		564737 RHOQ_HUMAN (4-187): 2.01e-82: 244: 60.87		PKHG1_HUMAN (1168-1638): 2.27e-44: 179: 16.46
+	Hs
		564483 RHOQ_HUMAN (4-187): 2.01e-82: 244: 60.87		SPTB2_HUMAN (492-1296): 2.04e-43: 176: 10.46
+	Hs
		925201 RAC1_HUMAN (1-191): 2.82e-82: 243: 82.81		SPTB2_HUMAN (492-1296): 2.04e-43: 176: 10.46
+	Hs
		166482 RAC1_HUMAN (1-191): 2.82e-82: 243: 82.81		MCF2L_HUMAN (8-498): 1.17e-40: 166: 18.65
+	Hs
		224711 RAC1_HUMAN (1-191): 2.82e-82: 243: 82.81		KALRN_HUMAN (81-1588): 3.59e-38: 159: 11.32
+	Hs
		279854 RAC1_HUMAN (1-191): 2.82e-82: 243: 82.81		TRIO_HUMAN (1194-1638): 1.38e-34: 147: 21.60
+	Hs
		500934 RAC1_HUMAN (1-191): 2.82e-82: 243: 82.81		MCF2_HUMAN (88-500): 3.84e-31: 135: 14.19
+	Hs
		297823 RAC1_HUMAN (1-191): 2.82e-82: 243: 82.81		K0754_HUMAN (131-1383): 1.62e-29: 131: 9.75
+	Hs
		564519 RHOQ_HUMAN (4-187): 2.01e-82: 244: 60.87		SPTN1_HUMAN (154-731): 2.78e-25: 117: 11.20
+	Hs
		925265 RAC1_HUMAN (1-191): 2.82e-82: 243: 82.81		SPTN1_HUMAN (154-731): 2.78e-25: 117: 11.20
+	Hs
		164564 RHOQ_HUMAN (4-187): 2.01e-82: 244: 60.87		SPTN2_HUMAN (104-772): 2.79e-17: 91: 10.16
+	Hs
		724757 RAC1_HUMAN (1-191): 2.82e-82: 243: 82.81		MYH9_HUMAN (65-689): 1.61e-17: 91.7: 8.95
+	Hs
		164599 RAC1_HUMAN (1-191): 2.82e-82: 243: 82.81		SPTN2_HUMAN (104-772): 2.79e-17: 91: 10.16
+	Hs
		564488 RHOQ_HUMAN (4-187): 2.01e-82: 244: 60.87		DYST_HUMAN (225-1201): 1.35e-10: 69: 9.69
+	Hs
		925215 RAC1_HUMAN (1-191): 2.82e-82: 243: 82.81		DYST_HUMAN (225-1201): 1.35e-10: 69: 9.69