HitPredict

Interactor 1: GCN5 (Q03330)
Histone acetyltransferase GCN5 (EC 2.3.1.48) (Histone crotonyltransferase GCN5) (EC 2.3.1.-)
Gene: GCN5

Interactor 2: H2AZ (Q12692)
Histone H2A.Z
Gene: HTZ1

Species: Saccharomyces cerevisiae S288C

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.68	0.60	0.641

Property	Details
Experiments	16239141, 16543219, 21179020
Identification Methods	affinity chromatography technology, enzymatic study, tandem affinity purification
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0006325 - chromatin organization GO:0006338 - chromatin remodeling GO:0006357 - regulation of transcription by RNA polymerase II
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 439 Sc			1 134
+	Sc
		392189 GCN5_YEAST (1-439): 0: 543: 100.00		H2A1_YEAST (23-133): 7.94e-52: 162: 62.50
+	Sc
		392549 GCN5_YEAST (1-439): 0: 543: 100.00		H2A2_YEAST (23-133): 1.36e-51: 161: 62.50
+	Mm
		1151749 KAT2B_MOUSE (1-430): 0: 535: 39.59		H2A2A_MOUSE (7-133): 1.23e-51: 161: 55.47
+	Hs
		1087073 KAT2B_HUMAN (2-430): 0: 527: 39.22		H2A2C_HUMAN (7-134): 6.76e-52: 162: 55.04
+	Hs
		1087072 KAT2A_HUMAN (14-430): 5.17e-171: 502: 38.30		H2A2C_HUMAN (7-134): 6.76e-52: 162: 55.04
+	Hs
		391825 KAT2B_HUMAN (2-430): 0: 527: 39.22		H2A1B_HUMAN (8-126): 5.7e-31: 108: 60.83
+	At
		286875 GCN5_ARATH (67-429): 1.31e-156: 456: 44.68		H2A3_ARATH (7-134): 3e-52: 163: 55.81
+	Hs
		391824 KAT2A_HUMAN (14-430): 5.17e-171: 502: 38.30		H2A1B_HUMAN (8-126): 5.7e-31: 108: 60.83
+	Hs
		998781 EP300_HUMAN (253-431): 1.9e-39: 153: 23.40		H2A2C_HUMAN (7-134): 6.76e-52: 162: 55.04
+	Hs
		998866 EP300_HUMAN (253-431): 1.9e-39: 153: 23.40		H2A2B_HUMAN (7-129): 3.24e-52: 162: 56.45
+	Mm
		101453 F8VPR5_MOUSE (256-431): 1.8e-39: 153: 23.46		H2A3_MOUSE (7-133): 1.38e-51: 161: 57.03
+	Mm
		70932 EP300_MOUSE (257-431): 4.09e-38: 149: 23.08		H2A3_MOUSE (7-133): 1.38e-51: 161: 57.03
+	Hs
		1066979 BRD3_HUMAN (303-435): 2.85e-36: 143: 30.44		H2A2C_HUMAN (7-134): 6.76e-52: 162: 55.04
+	Hs
		1067038 BRD3_HUMAN (303-435): 2.85e-36: 143: 30.44		H2A2B_HUMAN (7-129): 3.24e-52: 162: 56.45
+	Hs
		1067005 BRD3_HUMAN (303-435): 2.85e-36: 143: 30.44		H2A2A_HUMAN (7-133): 1.23e-51: 161: 55.47
+	Hs
		470198 BAZ2A_HUMAN (234-437): 2.83e-41: 159: 21.40		H2AZ_HUMAN (10-134): 6.73e-41: 134: 67.72
+	Hs
		470008 BPTF_HUMAN (327-431): 3.85e-37: 147: 41.91		H2AZ_HUMAN (10-134): 6.73e-41: 134: 67.72
+	Hs
		1067021 BRD3_HUMAN (303-435): 2.85e-36: 143: 30.44		H2AV_HUMAN (10-134): 1.67e-40: 133: 67.72
+	Hs
		391671 EP300_HUMAN (253-431): 1.9e-39: 153: 23.40		H2A1B_HUMAN (8-126): 5.7e-31: 108: 60.83
+	Hs
		243783 BRD4_HUMAN (256-438): 5.45e-36: 143: 25.53		H2A1B_HUMAN (8-126): 5.7e-31: 108: 60.83