HitPredict

Interactor 1: GNDS (Q03385)
Ral guanine nucleotide dissociation stimulator (RalGDS) (Ral guanine nucleotide exchange factor) (RalGEF)
Gene: Ralgds

Interactor 2: RASH (Q61411)
GTPase HRas (EC 3.6.5.2) (H-Ras-1) (Transforming protein p21) (c-H-ras) (p21ras) [Cleaved into: GTPase HRas, N-terminally processed]
Gene: Hras

Species: Mus musculus

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.621

Property	Details
Experiments	9144171
Identification Methods	two hybrid
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	RA~Ras, Ras~RasGEF, Ras~RasGEF_N
Common GO terms	GO:0005886 - plasma membrane GO:0007265 - Ras protein signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 852 Mm			1 189
+	Hs
		350126 GNDS_HUMAN (6-852): 0: 785: 85.48		RASK_HUMAN (1-188): 2.04e-84: 248: 86.24
+	Hs
		349279 GNDS_HUMAN (6-852): 0: 785: 85.48		RASH_HUMAN (16-189): 5.68e-73: 219: 100.00
+	Hs
		897883 GNDS_HUMAN (6-852): 0: 785: 85.48		RAP1B_HUMAN (1-165): 2.18e-63: 195: 57.49
+	Hs
		919618 GNDS_HUMAN (6-852): 0: 785: 85.48		RAP1A_HUMAN (1-165): 3.2e-62: 192: 56.89
+	Hs
		1021726 GNDS_HUMAN (6-852): 0: 785: 85.48		RIT1_HUMAN (3-167): 1.65e-56: 179: 51.81
+	Hs
		905420 GNDS_HUMAN (6-852): 0: 785: 85.48		RRAS2_HUMAN (3-188): 6.39e-57: 179: 55.26
+	Hs
		348971 RGL1_HUMAN (101-844): 0: 608: 40.03		RASN_HUMAN (1-188): 6.47e-88: 257: 85.64
+	Hs
		349692 RGL1_HUMAN (101-844): 0: 608: 40.03		RASH_HUMAN (16-189): 5.68e-73: 219: 100.00
+	Hs
		897964 RGL1_HUMAN (101-844): 0: 608: 40.03		RAP1B_HUMAN (1-165): 2.18e-63: 195: 57.49
+	Hs
		919681 RGL1_HUMAN (101-844): 0: 608: 40.03		RAP1A_HUMAN (1-165): 3.2e-62: 192: 56.89
+	Hs
		1273185 RGL1_HUMAN (101-844): 0: 608: 40.03		RIT1_HUMAN (3-167): 1.65e-56: 179: 51.81
+	Hs
		905457 RGL1_HUMAN (101-844): 0: 608: 40.03		RRAS2_HUMAN (3-188): 6.39e-57: 179: 55.26
+	Dm
		443004 Q9GR11_DROME (12-825): 1.59e-167: 506: 24.73		RAS1_DROME (1-175): 3.05e-92: 268: 81.22
+	Hs
		348697 RGL3_HUMAN (7-828): 8.88e-171: 513: 29.35		RASN_HUMAN (1-188): 6.47e-88: 257: 85.64
+	Mm
		1113379 RGL3_MOUSE (7-836): 1.21e-177: 530: 29.70		RASH_MOUSE (16-189): 5.68e-73: 219: 100.00
+	Hs
		349360 RGL3_HUMAN (7-828): 8.88e-171: 513: 29.35		RASH_HUMAN (16-189): 5.68e-73: 219: 100.00
+	Mm
		936775 RGL3_MOUSE (7-836): 1.21e-177: 530: 29.70		RIT1_MOUSE (3-167): 4.88e-57: 180: 51.81
+	Dm
		442968 Q9GR11_DROME (12-825): 1.59e-167: 506: 24.73		RAP1_DROME (1-163): 4.53e-64: 197: 58.54
+	Hs
		1109718 RGL3_HUMAN (7-828): 8.88e-171: 513: 29.35		RIT1_HUMAN (3-167): 1.65e-56: 179: 51.81
+	Hs
		905428 RGL3_HUMAN (7-828): 8.88e-171: 513: 29.35		RRAS2_HUMAN (3-188): 6.39e-57: 179: 55.26