HitPredict

Interactor 1: VPS60 (Q03390)
Vacuolar protein-sorting-associated protein 60 (Charged multivesicular body protein 5)
Gene: VPS60

Interactor 2: VPS20 (Q04272)
Vacuolar protein sorting-associated protein 20 (Amino acid sensor-independent protein 10) (Charged multivesicular body protein 6) (ESCRT-III complex subunit VPS20) (Vacuolar protein-targeting protein 20)
Gene: VPS20

Species: Saccharomyces cerevisiae S288C

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	1.00	0.754

Property	Details
Experiments	31273031, 35445263
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Snf7~Snf7
Common GO terms	GO:0005737 - cytoplasm GO:0005771 - multivesicular body GO:0006900 - vesicle budding from membrane GO:0015031 - protein transport GO:0032511 - late endosome to vacuole transport via multivesicular body sorting pathway
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 229 Sc			1 221
+	Hs
		92838 E9PSI1_HUMAN (1-217): 7.14e-60: 203: 17.97		CHM4B_HUMAN (11-218): 1.41e-37: 132: 19.05
+	Zm
		77175 B4FU00_MAIZE (1-229): 3.32e-47: 157: 25.43		B4FU00_MAIZE (2-215): 1.85e-42: 144: 20.74
+	At
		98408 F4JXR3_ARATH (1-229): 7.07e-52: 170: 20.07		VP322_ARATH (5-219): 7.24e-34: 122: 14.22
+	Hs
		1260649 CHMP7_HUMAN (5-219): 1.41e-39: 143: 17.97		CHM4C_HUMAN (2-216): 4.33e-41: 141: 20.18
+	Hs
		1349474 CHMP5_HUMAN (1-225): 7.1e-43: 146: 28.44		CHMP5_HUMAN (2-198): 7.26e-40: 138: 25.13
+	At
		1339085 VP601_ARATH (1-229): 2.23e-48: 160: 22.36		VP322_ARATH (5-219): 7.24e-34: 122: 14.22
+	Hs
		1286650 CHM4C_HUMAN (1-229): 1.15e-40: 140: 17.75		CHM4C_HUMAN (2-216): 4.33e-41: 141: 20.18
+	Dm
		1249822 CHMP5_DROME (1-228): 9.42e-43: 145: 27.19		CHM4_DROME (4-221): 6.03e-38: 133: 21.27
+	Hs
		1330527 CHMP5_HUMAN (1-225): 7.1e-43: 146: 28.44		CHM4B_HUMAN (11-218): 1.41e-37: 132: 19.05
+	At
		287073 VP601_ARATH (1-229): 2.23e-48: 160: 22.36		VP321_ARATH (5-213): 1.48e-31: 116: 19.43
+	Hs
		1260663 CHMP7_HUMAN (5-219): 1.41e-39: 143: 17.97		CHM4B_HUMAN (11-218): 1.41e-37: 132: 19.05
+	Hs
		1286698 CHM4C_HUMAN (1-229): 1.15e-40: 140: 17.75		CHM4B_HUMAN (11-218): 1.41e-37: 132: 19.05
+	Ce
		183904 Q18886_CAEEL (2-222): 2.41e-42: 144: 19.46		O16458_CAEEL (3-200): 3.34e-35: 125: 21.00
+	Hs
		1316082 CHMP5_HUMAN (1-225): 7.1e-43: 146: 28.44		CHM4A_HUMAN (3-217): 6.52e-34: 122: 21.56
+	Hs
		1260658 CHMP7_HUMAN (5-219): 1.41e-39: 143: 17.97		CHM4A_HUMAN (3-217): 6.52e-34: 122: 21.56
+	Hs
		1286687 CHM4C_HUMAN (1-229): 1.15e-40: 140: 17.75		CHM4A_HUMAN (3-217): 6.52e-34: 122: 21.56
+	Sc
		764882 VPS60_YEAST (1-229): 6.19e-42: 143: 100.00		SNF7_YEAST (12-219): 1.57e-29: 111: 17.35
+	Sc
		976147 VPS60_YEAST (1-229): 6.19e-42: 143: 100.00		VPS60_YEAST (2-216): 2.92e-23: 94.9: 15.63