HitPredict

Interactor 1: NMDE4 (Q03391)
Glutamate receptor ionotropic, NMDA 2D (GluN2D) (Glutamate [NMDA] receptor subunit epsilon-4) (N-methyl D-aspartate receptor subtype 2D) (NMDAR2D) (NR2D)
Gene: Grin2d

Interactor 2: DLG4 (Q62108)
Disks large homolog 4 (Postsynaptic density protein 95) (PSD-95) (Synapse-associated protein 90) (SAP-90) (SAP90)
Gene: DLG4

Species: Mus musculus

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.78 0.60 0.684

The method score is based on:

Property Details
Experiments 27507650, 28671696, 9647694, 19455133
Identification Methods affinity chromatography technology, two hybrid, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation
Interaction Type physical association, direct interaction, association

The annotation score is based on:

Property Details
Interacting Pfam domains -
Common GO terms GO:0005886 - plasma membrane
GO:0045202 - synapse
GO:0045211 - postsynaptic membrane
GO:0048168 - regulation of neuronal synaptic plasticity
GO:0098839 - postsynaptic density membrane
and 2 others

more...
Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 1323
Mm

1 724
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Service provided by Combinatics, Japan

Last updated: 15 Jul 2024