HitPredict

Interactor 1: ERCC6 (Q03468)
DNA excision repair protein ERCC-6 (EC 3.6.4.-) (ATP-dependent helicase ERCC6) (Cockayne syndrome protein CSB)
Gene: ERCC6

Interactor 2: HDAC2 (Q92769)
Histone deacetylase 2 (HD2) (EC 3.5.1.98) (Protein deacylase HDAC2) (EC 3.5.1.-)
Gene: HDAC2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.60	0.501

Property	Details
Experiments	31722399
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003682 - chromatin binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0006338 - chromatin remodeling GO:0045944 - positive regulation of transcription by RNA polymerase II
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1493 Hs			1 488
+	Hs
		976446 ERCC6_HUMAN (1-1493): 0: 1168: 100.00		HDAC1_HUMAN (1-443): 0: 642: 90.07
+	Hs
		1255037 CHD5_HUMAN (300-1446): 0: 783: 19.15		HDAC2_HUMAN (1-488): 0: 707: 100.00
+	Hs
		1059770 CHD4_HUMAN (303-1439): 0: 766: 18.35		HDAC2_HUMAN (1-488): 0: 707: 100.00
+	Mm
		56900 CHD5_MOUSE (300-1442): 0: 764: 19.19		HDAC2_MOUSE (1-488): 0: 704: 99.39
+	Hs
		1018617 CHD3_HUMAN (303-1446): 0: 759: 19.68		HDAC2_HUMAN (1-488): 0: 707: 100.00
+	Mm
		936393 Q5DTP7_MOUSE (303-1460): 0: 755: 18.76		HDAC2_MOUSE (1-488): 0: 704: 99.39
+	Hs
		1038563 CHD5_HUMAN (300-1446): 0: 783: 19.15		HDAC1_HUMAN (1-443): 0: 642: 90.07
+	Mm
		56897 CHD5_MOUSE (300-1442): 0: 764: 19.19		HDAC1_MOUSE (1-443): 0: 645: 90.29
+	Hs
		1038382 CHD4_HUMAN (303-1439): 0: 766: 18.35		HDAC1_HUMAN (1-443): 0: 642: 90.07
+	Hs
		229453 SMCA5_HUMAN (368-1383): 0: 698: 20.75		HDAC2_HUMAN (1-488): 0: 707: 100.00
+	Hs
		1018465 CHD3_HUMAN (303-1446): 0: 759: 19.68		HDAC1_HUMAN (1-443): 0: 642: 90.07
+	Mm
		140286 CHD4_MOUSE (303-1460): 0: 752: 18.67		HDAC1_MOUSE (1-443): 0: 645: 90.29
+	Hs
		847037 SMCA4_HUMAN (228-1324): 0: 677: 19.90		HDAC2_HUMAN (1-488): 0: 707: 100.00
+	Hs
		1038730 CHD8_HUMAN (2-1474): 0: 725: 16.46		HDAC1_HUMAN (1-443): 0: 642: 90.07
+	Dm
		332806 CHDM_DROME (281-1433): 0: 679: 17.12		HDAC1_DROME (5-472): 0: 653: 77.92
+	Hs
		846962 SMCA4_HUMAN (228-1324): 0: 677: 19.90		HDAC1_HUMAN (1-443): 0: 642: 90.07
+	Ce
		184848 CHD3_CAEEL (245-1380): 0: 684: 18.74		HDA1_CAEEL (7-456): 0: 595: 64.02
+	Hs
		177241 SMCA4_HUMAN (228-1324): 0: 677: 19.90		HDAC3_HUMAN (10-431): 0: 574: 58.26
+	Mm
		59025 CHD6_MOUSE (107-1487): 0: 825: 17.52		HDAC4_MOUSE (1-377): 6.12e-133: 412: 23.89
+	Mm
		1000158 CHD8_MOUSE (177-1474): 0: 725: 16.75		HDAC4_MOUSE (1-377): 6.12e-133: 412: 23.89