HitPredict

Interactor 1: ERCC6 (Q03468)
DNA excision repair protein ERCC-6 (EC 3.6.4.-) (ATP-dependent helicase ERCC6) (Cockayne syndrome protein CSB)
Gene: ERCC6

Interactor 2: CUL5 (Q93034)
Cullin-5 (CUL-5) (Vasopressin-activated calcium-mobilizing receptor 1) (VACM-1)
Gene: CUL5

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.60	0.501

Property	Details
Experiments	28292928
Identification Methods	fluorescent resonance energy transfer
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0090734 - site of DNA damage
Homologous interactions	12

Homologous interactions

Color coding for hit scores

	1 1493 Hs			1 780
+	Hs
		976447 ERCC6_HUMAN (1-1493): 0: 1168: 100.00		CUL4A_HUMAN (16-780): 0: 744: 24.48
+	Hs
		976448 ERCC6_HUMAN (1-1493): 0: 1168: 100.00		CUL4B_HUMAN (16-780): 0: 736: 25.39
+	Hs
		1041592 CHD4_HUMAN (303-1439): 0: 766: 18.35		CUL3_HUMAN (8-780): 0: 754: 22.96
+	Hs
		1042986 CHD4_HUMAN (303-1439): 0: 766: 18.35		CUL4A_HUMAN (16-780): 0: 744: 24.48
+	Hs
		229457 SMCA5_HUMAN (368-1383): 0: 698: 20.75		CUL5_HUMAN (1-780): 0: 792: 100.00
+	Hs
		846965 SMCA4_HUMAN (228-1324): 0: 677: 19.90		CUL3_HUMAN (8-780): 0: 754: 22.96
+	Hs
		846964 SMCA4_HUMAN (228-1324): 0: 677: 19.90		CUL1_HUMAN (11-780): 0: 748: 27.84
+	Hs
		846966 SMCA4_HUMAN (228-1324): 0: 677: 19.90		CUL4A_HUMAN (16-780): 0: 744: 24.48
+	Hs
		846967 SMCA4_HUMAN (228-1324): 0: 677: 19.90		CUL4B_HUMAN (16-780): 0: 736: 25.39
+	Hs
		846769 SMCA2_HUMAN (228-1247): 0: 660: 19.72		CUL4A_HUMAN (16-780): 0: 744: 24.48
+	Hs
		163605 BTAF1_HUMAN (490-1019): 9.59e-80: 293: 35.50		CUL3_HUMAN (8-780): 0: 754: 22.96
+	Hs
		1042949 RA54B_HUMAN (502-1007): 8.21e-77: 276: 34.33		CUL3_HUMAN (8-780): 0: 754: 22.96