HitPredict

Interactor 1: CEF1 (Q03654)
Pre-mRNA-splicing factor CEF1 (PRP nineteen-associated complex protein 85) (PRP19-associated complex protein 85)
Gene: CEF1

Interactor 2: CWC2 (Q12046)
Pre-mRNA-splicing factor CWC2 (Complexed with CEF1 protein 2) (PRP19-associated complex protein 40) (Synthetic lethal with CLF1 protein 3)
Gene: CWC2

Species: Saccharomyces cerevisiae S288C

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.93	0.60	0.748

Property	Details
Experiments	11805826, 11884590, 37968396, 14690591, 16429126, 29146870, 30879786
Identification Methods	tandem affinity purification, affinity chromatography technology, pull down, biochemical
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000398 - mRNA splicing, via spliceosome GO:0000974 - Prp19 complex GO:0071006 - U2-type catalytic step 1 spliceosome
Homologous interactions	5

Homologous interactions

Color coding for hit scores

	1 590 Sc			1 339
+	Hs
		1303800 CDC5L_HUMAN (1-537): 2.19e-100: 324: 29.51		RBM22_HUMAN (5-253): 3.12e-81: 254: 20.93
+	At
		955174 CDC5L_ARATH (4-461): 1.98e-82: 277: 30.84		C3H4_ARATH (8-259): 3.02e-79: 251: 21.29
+	At
		186560 O22179_ARATH (10-126): 1.38e-42: 156: 27.12		C3H25_ARATH (8-259): 1.22e-81: 257: 21.21
+	Hs
		963563 CDC5L_HUMAN (1-537): 2.19e-100: 324: 29.51		TIAR_HUMAN (7-257): 5.64e-14: 74.1: 15.83
+	Hs
		165554 CDC5L_HUMAN (1-537): 2.19e-100: 324: 29.51		SR140_HUMAN (123-296): 1.8e-12: 70.3: 18.56