HitPredict

Interactor 1: GLRX3 (Q03835)
Monothiol glutaredoxin-3
Gene: GRX3

Interactor 2: BOL1 (Q3E793)
BolA-like protein 1
Gene: BOL1

Species: Saccharomyces cerevisiae S288C

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.60	1.00	0.775

Property	Details
Experiments	18719252, 37968396
Identification Methods	two hybrid, affinity chromatography technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	BolA~Glutaredoxin
Common GO terms	GO:0006879 - intracellular iron ion homeostasis GO:0016226 - iron-sulfur cluster assembly GO:1990229 - iron-sulfur cluster assembly complex
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 250 Sc			1 110
+	Sc
		697331 GLRX4_YEAST (1-249): 5.5e-66: 206: 66.27		BOL1_YEAST (1-110): 5.98e-41: 132: 100.00
+	Sc
		858951 GLRX3_YEAST (1-250): 8.59e-73: 224: 100.00		BOL2_YEAST (2-105): 1.81e-20: 81.1: 21.91
+	Sp
		251934 GLRX4_SCHPO (1-245): 2.03e-64: 202: 42.45		UVI31_SCHPO (1-104): 1.93e-27: 98.5: 44.34
+	Hs
		280488 GLRX3_HUMAN (8-244): 2.98e-57: 187: 37.13		BOLA1_HUMAN (3-110): 9.42e-33: 113: 31.48
+	Sc
		697322 GLRX4_YEAST (1-249): 5.5e-66: 206: 66.27		BOL2_YEAST (2-105): 1.81e-20: 81.1: 21.91
+	Sp
		145312 GLRX4_SCHPO (1-245): 2.03e-64: 202: 42.45		YETB_SCHPO (27-107): 2.99e-22: 84.6: 22.22
+	Sc
		763750 GLRX3_YEAST (1-250): 8.59e-73: 224: 100.00		BOL3_YEAST (8-100): 2.72e-12: 60.3: 23.66
+	Hs
		280471 GLRX3_HUMAN (8-244): 2.98e-57: 187: 37.13		BOLA2_HUMAN (25-110): 1.14e-24: 90.8: 26.14
+	Sc
		697320 GLRX4_YEAST (1-249): 5.5e-66: 206: 66.27		BOL3_YEAST (8-100): 2.72e-12: 60.3: 23.66
+	At
		1147353 GRS14_ARATH (149-246): 7.63e-42: 142: 47.96		BOLA1_ARATH (2-108): 2.33e-33: 115: 36.45
+	At
		1147356 GRS15_ARATH (92-246): 4.12e-42: 142: 31.65		BOLA1_ARATH (2-108): 2.33e-33: 115: 36.45
+	At
		1196490 GRS14_ARATH (149-246): 7.63e-42: 142: 47.96		SUFE1_ARATH (8-104): 1.59e-30: 113: 37.37
+	At
		1196493 GRS15_ARATH (92-246): 4.12e-42: 142: 31.65		SUFE1_ARATH (8-104): 1.59e-30: 113: 37.37
+	Dm
		53885 Q9VJZ6_DROME (1-246): 9.33e-52: 169: 33.33		A1Z933_DROME (21-106): 1.12e-21: 83.1: 26.74
+	Hs
		1197948 GLRX5_HUMAN (152-246): 6.13e-41: 139: 42.71		BOLA1_HUMAN (3-110): 9.42e-33: 113: 31.48
+	Hs
		280398 GLRX3_HUMAN (8-244): 2.98e-57: 187: 37.13		BOLA3_HUMAN (4-104): 8.31e-10: 53.4: 18.81
+	At
		1196707 GRS14_ARATH (149-246): 7.63e-42: 142: 47.96		BOLA2_ARATH (17-110): 2.75e-21: 82.3: 27.08
+	At
		1227407 GRS15_ARATH (92-246): 4.12e-42: 142: 31.65		BOLA2_ARATH (17-110): 2.75e-21: 82.3: 27.08
+	Dm
		53878 Q8SXQ5_DROME (151-246): 4.18e-41: 140: 43.75		A1Z933_DROME (21-106): 1.12e-21: 83.1: 26.74
+	Hs
		1121855 GLRX5_HUMAN (152-246): 6.13e-41: 139: 42.71		BOLA3_HUMAN (4-104): 8.31e-10: 53.4: 18.81