HitPredict

Interactor 1: TF65 (Q04206)
Transcription factor p65 (Nuclear factor NF-kappa-B p65 subunit) (Nuclear factor of kappa light polypeptide gene enhancer in B-cells 3)
Gene: RELA

Interactor 2: REL (Q04864)
Proto-oncogene c-Rel
Gene: REL

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.96 1.00 0.983

The method score is based on:

Property Details
Experiments 25416956, 26186194, 28514442, 14743216, 27609421, 8139561, 11967310, 33961781, 29084252, 10498867, 35271311, 15818410
Identification Methods two hybrid, affinity chromatography technology, pull down, tandem affinity purification, anti tag coimmunoprecipitation, two hybrid prey pooling approach, two hybrid array, validated two hybrid
Interaction Type direct interaction, physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains RHD_dimer~RHD_dimer, RHD_DNA_bind~RHD_dimer, RHD_DNA_bind~RHD_DNA_bind
Common GO terms GO:0000785 - chromatin
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001228 - DNA-binding transcription activator activity, RNA polymerase II-specific
GO:0003700 - DNA-binding transcription factor activity
and 11 others

more...
Homologous interactions 19

Homologous interactions

Color coding for hit scores

1 551
Hs

1 619
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Last updated: 15 Jul 2024