HitPredict

Interactor 1: TF65 (Q04206)
Transcription factor p65 (Nuclear factor NF-kappa-B p65 subunit) (Nuclear factor of kappa light polypeptide gene enhancer in B-cells 3)
Gene: RELA

Interactor 2: TLE5 (Q08117)
TLE family member 5 (Amino-terminal enhancer of split) (Amino enhancer of split) (Gp130-associated protein GAM) (Grg-5) (Groucho-related protein 5) (Protein ESP1) (Protein GRG) (TLE family member 5, transcriptional modulator)
Gene: TLE5

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.67	0.60	0.636

Property	Details
Experiments	10660609, 15489227
Identification Methods	two hybrid, pull down, affinity chromatography technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0005634 - nucleus GO:0005667 - transcription regulator complex GO:0045892 - negative regulation of DNA-templated transcription GO:0070555 - response to interleukin-1
Homologous interactions	3

Homologous interactions

Color coding for hit scores

	1 551 Hs			1 197
+	Hs
		978719 TF65_HUMAN (1-551): 0: 601: 100.00		TLE1_HUMAN (2-197): 2.47e-111: 336: 64.50
+	Hs
		981558 REL_HUMAN (12-523): 3.56e-165: 484: 41.64		TLE5_HUMAN (1-197): 3.1e-101: 292: 100.00
+	Dm
		547606 DORS_DROME (16-541): 1.56e-139: 430: 30.94		GROU_DROME (2-163): 3.54e-59: 198: 54.44