HitPredict

Interactor 1: TF65 (Q04206)
Transcription factor p65 (Nuclear factor NF-kappa-B p65 subunit) (Nuclear factor of kappa light polypeptide gene enhancer in B-cells 3)
Gene: RELA

Interactor 2: SIR1 (Q96EB6)
NAD-dependent protein deacetylase sirtuin-1 (hSIRT1) (EC 2.3.1.286) (NAD-dependent protein deacylase sirtuin-1) (EC 2.3.1.-) (Regulatory protein SIR2 homolog 1) (SIR2-like protein 1) (hSIR2) [Cleaved into: SirtT1 75 kDa fragment (75SirT1)]
Gene: SIRT1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.81	0.60	0.700

The method score is based on:

Property	Details
Experiments	17041012, 21245135, 15152190, 21081649
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation, anti bait coimmunoprecipitation, deacetylase assay
Interaction Type	physical association, association, deacetylation reaction

The annotation score is based on:

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0000785 - chromatin GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm and 12 others more... GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0006325 - chromatin organization GO:0008284 - positive regulation of cell population proliferation GO:0019899 - enzyme binding GO:0032868 - response to insulin GO:0043066 - negative regulation of apoptotic process GO:0045892 - negative regulation of DNA-templated transcription GO:0045944 - positive regulation of transcription by RNA polymerase II GO:0070301 - cellular response to hydrogen peroxide GO:0071356 - cellular response to tumor necrosis factor GO:0140297 - DNA-binding transcription factor binding
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1	551
Hs

1	747

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024