HitPredict

Interactor 1: TF65 (Q04206)
Transcription factor p65 (Nuclear factor NF-kappa-B p65 subunit) (Nuclear factor of kappa light polypeptide gene enhancer in B-cells 3)
Gene: RELA

Interactor 2: NEMO (Q9Y6K9)
NF-kappa-B essential modulator (NEMO) (FIP-3) (IkB kinase-associated protein 1) (IKKAP1) (Inhibitor of nuclear factor kappa-B kinase subunit gamma) (I-kappa-B kinase subunit gamma) (IKK-gamma) (IKKG) (IkB kinase subunit gamma) (NF-kappa-B essential modifier)
Gene: IKBKG

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.72	0.60	0.660

The method score is based on:

Property	Details
Experiments	35271311, 18519641, 36398858
Identification Methods	affinity chromatography technology, enzymatic study, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

The annotation score is based on:

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0006954 - inflammatory response and 8 others more... GO:0007249 - canonical NF-kappaB signal transduction GO:0031625 - ubiquitin protein ligase binding GO:0042803 - protein homodimerization activity GO:0043123 - positive regulation of canonical NF-kappaB signal transduction GO:0045087 - innate immune response GO:0045944 - positive regulation of transcription by RNA polymerase II GO:0050862 - positive regulation of T cell receptor signaling pathway GO:0051092 - positive regulation of NF-kappaB transcription factor activity
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1	551
Hs

1	419

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024