HitPredict

Interactor 1: BTG2 (Q04211)
Protein BTG2 (BTG family member 2) (NGF-inducible protein TIS21)
Gene: BTG2

Interactor 2: CNOT7 (Q60809)
CCR4-NOT transcription complex subunit 7 (EC 3.1.13.4) (CCR4-associated factor 1) (CAF-1)
Gene: CNOT7

Species: Mus musculus

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.55	1.00	0.743

Property	Details
Experiments	20211142, 18337750
Identification Methods	two hybrid array, pull down
Interaction Type	physical association

Property	Details
Interacting Pfam domains	BTG~CAF1
Common GO terms	GO:0003714 - transcription corepressor activity GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0008285 - negative regulation of cell population proliferation GO:0060213 - positive regulation of nuclear-transcribed mRNA poly(A) tail shortening
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 158 Mm			1 285
+	Hs
		944599 BTG2_HUMAN (1-158): 1.08e-88: 257: 93.67		CNOT7_HUMAN (1-285): 0: 507: 99.65
+	Mm
		978995 BTG2_MOUSE (1-158): 1.33e-89: 259: 100.00		CNOT8_MOUSE (1-282): 2.91e-175: 486: 76.60
+	Hs
		944598 BTG2_HUMAN (1-158): 1.08e-88: 257: 93.67		CNOT8_HUMAN (1-282): 1.21e-175: 487: 76.60
+	Hs
		1152299 Q6IBC8_HUMAN (3-158): 4.02e-77: 228: 60.84		CNOT7_HUMAN (1-285): 0: 507: 99.65
+	Hs
		912794 BTG1_HUMAN (3-158): 4.02e-77: 228: 60.84		CNOT7_HUMAN (1-285): 0: 507: 99.65
+	Mm
		912801 BTG1_MOUSE (3-158): 4.02e-77: 228: 60.84		CNOT7_MOUSE (1-285): 0: 507: 100.00
+	Hs
		1152298 Q6IBC8_HUMAN (3-158): 4.02e-77: 228: 60.84		CNOT8_HUMAN (1-282): 1.21e-175: 487: 76.60
+	Hs
		912793 BTG1_HUMAN (3-158): 4.02e-77: 228: 60.84		CNOT8_HUMAN (1-282): 1.21e-175: 487: 76.60
+	Mm
		912802 BTG1_MOUSE (3-158): 4.02e-77: 228: 60.84		CNOT8_MOUSE (1-282): 2.91e-175: 486: 76.60
+	Hs
		841404 TOB1_HUMAN (9-123): 8.46e-57: 182: 42.61		CNOT7_HUMAN (1-285): 0: 507: 99.65
+	Hs
		1048317 TOB2_HUMAN (9-123): 7.34e-53: 172: 40.87		CNOT7_HUMAN (1-285): 0: 507: 99.65
+	Hs
		841403 TOB1_HUMAN (9-123): 8.46e-57: 182: 42.61		CNOT8_HUMAN (1-282): 1.21e-175: 487: 76.60
+	Mm
		251045 BTG4_MOUSE (9-116): 1.77e-47: 155: 40.00		CNOT7_MOUSE (1-285): 0: 507: 100.00
+	Hs
		1048316 TOB2_HUMAN (9-123): 7.34e-53: 172: 40.87		CNOT8_HUMAN (1-282): 1.21e-175: 487: 76.60
+	Hs
		1051207 BTG3_HUMAN (9-116): 4.6e-44: 147: 43.64		CNOT7_HUMAN (1-285): 0: 507: 99.65
+	Mm
		251046 BTG4_MOUSE (9-116): 1.77e-47: 155: 40.00		CNOT8_MOUSE (1-282): 2.91e-175: 486: 76.60
+	Hs
		1051204 BTG3_HUMAN (9-116): 4.6e-44: 147: 43.64		CNOT8_HUMAN (1-282): 1.21e-175: 487: 76.60
+	Dm
		1155377 Q6NQY2_DROME (9-125): 2.17e-51: 173: 39.32		Q9VTS4_DROME (2-273): 8.58e-159: 445: 72.26
+	Dm
		60235 A4V4L0_DROME (9-125): 1.18e-48: 165: 40.17		X2JCC3_DROME (2-256): 1.59e-146: 417: 68.87