HitPredict

Interactor 1: UTP15 (Q04305)
U3 small nucleolar RNA-associated protein 15 (U3 snoRNA-associated protein 15) (U three protein 15) (U3 protein 15 required for transcription) (t-UTP15)
Gene: UTP15

Interactor 2: UTP21 (Q06078)
U3 small nucleolar RNA-associated protein 21 (U3 snoRNA-associated protein 21) (U three protein 21)
Gene: UTP21

Species: Saccharomyces cerevisiae S288C

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.78	1.00	0.886

Property	Details
Experiments	12150911, 16429126, 28600509, 37968396
Identification Methods	affinity chromatography technology, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	ANAPC4_WD40~WD40
Common GO terms	GO:0005654 - nucleoplasm GO:0005730 - nucleolus GO:0006364 - rRNA processing GO:0030490 - maturation of SSU-rRNA GO:0030686 - 90S preribosome and 1 others more... GO:0032040 - small-subunit processome
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 513 Sc			1 939
+	Sc
		979264 UTP15_YEAST (1-513): 1.38e-108: 334: 100.00		UTP12_YEAST (11-323): 6.77e-59: 220: 10.06
+	Hs
		1240442 POC1B_HUMAN (2-291): 8.39e-83: 266: 15.25		POC1A_HUMAN (437-756): 6.33e-46: 172: 18.32
+	Sc
		635637 UTP15_YEAST (1-513): 1.38e-108: 334: 100.00		PWP2_YEAST (2-230): 8.49e-13: 74.6: 8.86
+	Dm
		1358859 FBXW7_DROME (6-371): 7.77e-78: 267: 14.59		WDS_DROME (616-781): 2.94e-25: 110: 14.97
+	Hs
		903418 FBXW7_HUMAN (5-371): 7.23e-77: 257: 14.47		WDR5_HUMAN (616-781): 6.74e-26: 111: 14.97
+	Hs
		1288390 SNR40_HUMAN (2-105): 9.6e-19: 89.5: 10.44		WDR3_HUMAN (4-578): 5.29e-77: 272: 9.64
+	Hs
		863508 FBXW7_HUMAN (5-371): 7.23e-77: 257: 14.47		COPA_HUMAN (198-595): 1.95e-15: 83.3: 11.77
+	Hs
		1246470 TBL1Y_HUMAN (9-286): 2.17e-62: 214: 13.33		WDR36_HUMAN (11-423): 5.53e-26: 117: 11.62
+	Hs
		1246488 NLE1_HUMAN (1-237): 7.9e-54: 190: 14.09		WDR36_HUMAN (11-423): 5.53e-26: 117: 11.62
+	Hs
		1016312 SNR40_HUMAN (2-105): 9.6e-19: 89.5: 10.44		TBL3_HUMAN (22-338): 4.53e-58: 216: 10.18
+	Hs
		903551 NLE1_HUMAN (1-237): 7.9e-54: 190: 14.09		WDR5_HUMAN (616-781): 6.74e-26: 111: 14.97
+	Hs
		1346954 NLE1_HUMAN (1-237): 7.9e-54: 190: 14.09		NLE1_HUMAN (653-785): 5.4e-17: 86.9: 9.70
+	Hs
		1074780 TAF5_HUMAN (25-189): 6.65e-21: 98.4: 22.35		TAF5_HUMAN (395-726): 4.24e-41: 164: 18.87
+	Hs
		792949 LIS1_HUMAN (244-453): 1.1e-35: 139: 9.05		WDR5_HUMAN (616-781): 6.74e-26: 111: 14.97
+	At
		1164331 TAF5_ARATH (25-213): 2.94e-24: 108: 20.31		TAF5_ARATH (491-695): 9.98e-24: 109: 14.96
+	Hs
		1246459 SNR40_HUMAN (2-105): 9.6e-19: 89.5: 10.44		WDR36_HUMAN (11-423): 5.53e-26: 117: 11.62
+	Hs
		903428 SNR40_HUMAN (2-105): 9.6e-19: 89.5: 10.44		WDR5_HUMAN (616-781): 6.74e-26: 111: 14.97
+	Sp
		999838 TUP11_SCHPO (282-428): 5.04e-20: 95.3: 13.55		TUP11_SCHPO (162-492): 3.02e-11: 69.4: 17.68
+	Hs
		863397 WDR5_HUMAN (333-420): 2.73e-12: 69.9: 10.23		COPA_HUMAN (198-595): 1.95e-15: 83.3: 11.77