HitPredict

Interactor 1: UBXN1 (Q04323)
UBX domain-containing protein 1 (SAPK substrate protein 1) (UBA/UBX 33.3 kDa protein)
Gene: UBXN1

Interactor 2: AMFR (Q9UKV5)
E3 ubiquitin-protein ligase AMFR (EC 2.3.2.36) (Autocrine motility factor receptor) (AMF receptor) (RING finger protein 45) (gp78)
Gene: AMFR

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	18775313
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005783 - endoplasmic reticulum GO:0005829 - cytosol GO:0043130 - ubiquitin binding
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 297 Hs			1 643
+	Mm
		1265759 UBXN1_MOUSE (1-297): 3.84e-69: 218: 92.93		AMFR_MOUSE (1-643): 0: 604: 94.40
+	Hs
		1267628 UBXN4_HUMAN (22-293): 5.83e-45: 160: 24.30		AMFR_HUMAN (1-643): 0: 593: 100.00
+	Hs
		299488 UBXN7_HUMAN (45-294): 2.33e-43: 156: 17.13		AMFR_HUMAN (1-643): 0: 593: 100.00
+	Hs
		1356612 FAF1_HUMAN (71-294): 1.76e-41: 153: 22.12		AMFR_HUMAN (1-643): 0: 593: 100.00
+	Hs
		1273586 UBP13_HUMAN (2-162): 3.18e-36: 139: 22.98		AMFR_HUMAN (1-643): 0: 593: 100.00
+	Hs
		1198639 UBXN4_HUMAN (22-293): 5.83e-45: 160: 24.30		SYVN1_HUMAN (73-642): 5.72e-95: 306: 17.60
+	Hs
		116689 UBXN8_HUMAN (75-294): 6.32e-35: 128: 15.32		SYVN1_HUMAN (73-642): 5.72e-95: 306: 17.60
+	Sc
		732562 UBX3_YEAST (78-293): 1.42e-34: 132: 13.73		TUL1_YEAST (156-384): 9.9e-31: 130: 14.07
+	Mm
		610620 UBS3B_MOUSE (5-73): 4.11e-16: 80.4: 46.38		CBL_MOUSE (293-550): 1.99e-37: 151: 18.73
+	Hs
		610459 UBS3B_HUMAN (5-73): 4.15e-16: 80.4: 46.38		CBL_HUMAN (293-550): 4.72e-35: 143: 19.37