HitPredict

Interactor 1: NOTC2 (Q04721)
Neurogenic locus notch homolog protein 2 (Notch 2) (hN2) [Cleaved into: Notch 2 extracellular truncation (N2ECD); Notch 2 intracellular domain (N2ICD)]
Gene: NOTCH2

Interactor 2: VASN (Q6EMK4)
Vasorin (Protein slit-like 2)
Gene: VASN

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	1.00	0.811

Property	Details
Experiments	28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	EGF~EGF, EGF~EGF_CA
Common GO terms	GO:0005886 - plasma membrane GO:0009986 - cell surface
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 2471 Hs			1 673
+	Hs
		296652 NOTC2_HUMAN (22-2471): 0: 1386: 100.00		SLIT2_HUMAN (152-376): 2.46e-27: 120: 18.80
+	Hs
		1150811 JAG2_HUMAN (2-501): 6.2e-66: 249: 33.21		VASN_HUMAN (1-673): 1.32e-131: 404: 100.00
+	Hs
		484635 NT2NC_HUMAN (1194-1404): 5.14e-17: 85.9: 33.92		VASN_HUMAN (1-673): 1.32e-131: 404: 100.00
+	Hs
		1150760 NT2NA_HUMAN (34-171): 1.94e-14: 77: 38.57		VASN_HUMAN (1-673): 1.32e-131: 404: 100.00
+	Hs
		965129 ANK2_HUMAN (1770-2394): 3.7e-103: 374: 17.01		R4RL2_HUMAN (24-387): 1.23e-22: 102: 31.81
+	Hs
		484644 NT2NC_HUMAN (1194-1404): 5.14e-17: 85.9: 33.92		LRFN4_HUMAN (24-638): 3.13e-89: 292: 22.70
+	Hs
		1162222 NT2NA_HUMAN (34-171): 1.94e-14: 77: 38.57		LRFN4_HUMAN (24-638): 3.13e-89: 292: 22.70