HitPredict

Interactor 1: NOTC2 (Q04721)
Neurogenic locus notch homolog protein 2 (Notch 2) (hN2) [Cleaved into: Notch 2 extracellular truncation (N2ECD); Notch 2 intracellular domain (N2ICD)]
Gene: NOTCH2

Interactor 2: STYK1 (Q6J9G0)
Tyrosine-protein kinase STYK1 (EC 2.7.10.2) (Novel oncogene with kinase domain) (Protein PK-unique) (Serine/threonine/tyrosine kinase 1)
Gene: STYK1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	35384245
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane GO:0043235 - receptor complex
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 2471 Hs			1 422
+	Hs
		872428 NOTC2_HUMAN (22-2471): 0: 1386: 100.00		EPHA5_HUMAN (2-408): 4.94e-121: 377: 20.33
+	Hs
		665584 NOTC2_HUMAN (22-2471): 0: 1386: 100.00		EPHB2_HUMAN (5-393): 2.02e-120: 376: 19.29
+	Hs
		434176 NOTC2_HUMAN (22-2471): 0: 1386: 100.00		RET_HUMAN (8-415): 2.01e-119: 375: 23.29
+	Hs
		980379 NOTC2_HUMAN (22-2471): 0: 1386: 100.00		EPHA7_HUMAN (36-414): 1.44e-120: 375: 19.37
+	Hs
		872634 NOTC2_HUMAN (22-2471): 0: 1386: 100.00		EPHA4_HUMAN (42-417): 8.52e-119: 370: 18.73
+	Hs
		607947 NOTC2_HUMAN (22-2471): 0: 1386: 100.00		FGFR4_HUMAN (80-392): 2.13e-119: 367: 28.79
+	Hs
		507971 ANK3_HUMAN (1672-2286): 2.46e-106: 385: 14.71		FGFR1_HUMAN (11-417): 2.76e-127: 388: 24.20
+	Hs
		507954 ANK2_HUMAN (1770-2394): 3.7e-103: 374: 17.01		FGFR1_HUMAN (11-417): 2.76e-127: 388: 24.20
+	Hs
		665591 ANK3_HUMAN (1672-2286): 2.46e-106: 385: 14.71		EPHB2_HUMAN (5-393): 2.02e-120: 376: 19.29
+	Hs
		434183 ANK3_HUMAN (1672-2286): 2.46e-106: 385: 14.71		RET_HUMAN (8-415): 2.01e-119: 375: 23.29
+	Hs
		665581 ANK2_HUMAN (1770-2394): 3.7e-103: 374: 17.01		EPHB2_HUMAN (5-393): 2.02e-120: 376: 19.29
+	Hs
		337391 NOTC1_HUMAN (2-1107): 2.62e-145: 509: 33.88		ABL1_HUMAN (143-387): 8.6e-41: 156: 35.34
+	Hs
		507831 ANK1_HUMAN (1936-2374): 4.06e-52: 205: 13.23		FGFR1_HUMAN (11-417): 2.76e-127: 388: 24.20
+	Dm
		422748 NOTCH_DROME (2-344): 3.6e-21: 104: 21.89		Q0KIF4_DROME (23-416): 6.89e-120: 375: 19.85
+	Hs
		434229 NT2NA_HUMAN (34-171): 1.94e-14: 77: 38.57		RET_HUMAN (8-415): 2.01e-119: 375: 23.29
+	Hs
		434309 NOTC3_HUMAN (1931-2465): 6.29e-11: 70.7: 16.82		RET_HUMAN (8-415): 2.01e-119: 375: 23.29
+	Hs
		337591 NOTC3_HUMAN (1931-2465): 6.29e-11: 70.7: 16.82		ABL1_HUMAN (143-387): 8.6e-41: 156: 35.34