HitPredict

Interactor 1: NOTC2 (Q04721)
Neurogenic locus notch homolog protein 2 (Notch 2) (hN2) [Cleaved into: Notch 2 extracellular truncation (N2ECD); Notch 2 intracellular domain (N2ICD)]
Gene: NOTCH2

Interactor 2: LRIQ1 (Q96JM4)
Leucine-rich repeat and IQ domain-containing protein 1
Gene: LRRIQ1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	0.50	0.574

Property	Details
Experiments	28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	-
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 2471 Hs			1 1722
+	Hs
		296652 NOTC2_HUMAN (22-2471): 0: 1386: 100.00		SLIT2_HUMAN (1035-1592): 2.9e-48: 192: 13.20
+	Hs
		1295426 NOTC3_HUMAN (1931-2465): 6.29e-11: 70.7: 16.82		LRIQ1_HUMAN (1-1722): 0: 1015: 100.00
+	Dm
		1180577 Q7YSQ1_DROME (1728-2239): 4.87e-110: 364: 43.99		TOLL7_DROME (1063-1200): 1.36e-09: 65.7: 12.86
+	Dm
		422907 NOTCH_DROME (2-344): 3.6e-21: 104: 21.89		Q9VT44_DROME (775-1176): 5.49e-43: 168: 18.68
+	Dm
		113994 M9PB30_DROME (32-567): 1.69e-11: 72.7: 16.61		Q9VT44_DROME (775-1176): 5.49e-43: 168: 18.68
+	Dm
		422776 NOTCH_DROME (2-344): 3.6e-21: 104: 21.89		TOLL7_DROME (1063-1200): 1.36e-09: 65.7: 12.86