Interactor 1: NOTC2 (Q04721)
Neurogenic locus notch homolog protein 2 (Notch 2) (hN2) [Cleaved into: Notch 2 extracellular truncation (N2ECD); Notch 2 intracellular domain (N2ICD)]
Gene: NOTCH2
Interactor 2: NOTC3 (Q9UM47)
Neurogenic locus notch homolog protein 3 (Notch 3) [Cleaved into: Notch 3 extracellular truncation; Notch 3 intracellular domain]
Gene: NOTCH3
Species: Homo sapiens
Source: intact
Category: High-throughput
Confidence: High
| Method score | Annotation score | Interaction score |
|---|---|---|
| 0.47 | 1.00 | 0.691 |
The method score is based on:
| Property | Details |
|---|---|
| Experiments | 33961781 |
| Identification Methods | affinity chromatography technology, anti tag coimmunoprecipitation |
| Interaction Type | physical association, association |
The annotation score is based on:
| Property | Details |
|---|---|
| Interacting Pfam domains | Ank~Ank, Ank~Ank_2, Ank~Ank_4, Ank_2~Ank_2, Ank_2~Ank_4, EGF~EGF, EGF~EGF_CA, EGF_CA~EGF_CA, NOD~NODP, NOD~Notch, NODP~NODP, NODP~Notch, Notch~Notch |
| Common GO terms | GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0000139 - Golgi membrane GO:0005112 - Notch binding GO:0005509 - calcium ion binding GO:0005576 - extracellular region and 12 others more... |
| Homologous interactions | 19 |
Homologous interactions
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Service provided by Combinatics, Japan
Last updated: 15 Jul 2024
