HitPredict

Interactor 1: TLE1 (Q04724)
Transducin-like enhancer protein 1 (E(Sp1) homolog) (Enhancer of split groucho-like protein 1) (ESG1)
Gene: TLE1

Interactor 2: HME1 (Q05925)
Homeobox protein engrailed-1 (Homeobox protein en-1) (Hu-En-1)
Gene: EN1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.85	0.60	0.716

Property	Details
Experiments	33961781, 19956621, 35140242, 16571670, 18611861
Identification Methods	affinity chromatography technology, proximity labelling technology, pull down, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 770 Hs			1 392
+	Hs
		829830 TLE1_HUMAN (1-770): 0: 594: 100.00		HXA1_HUMAN (140-376): 1.7e-32: 126: 21.99
+	Hs
		585946 TLE1_HUMAN (1-770): 0: 594: 100.00		HME2_HUMAN (44-392): 3.87e-26: 109: 42.98
+	Hs
		882121 TLE1_HUMAN (1-770): 0: 594: 100.00		GSC_HUMAN (160-391): 9.22e-27: 109: 19.92
+	Hs
		980663 TLE1_HUMAN (1-770): 0: 594: 100.00		HESX1_HUMAN (232-375): 1.5e-27: 109: 26.39
+	Hs
		980926 TLE4_HUMAN (1-770): 0: 562: 86.27		HME1_HUMAN (1-392): 1.5e-35: 136: 100.00
+	Hs
		882123 TLE4_HUMAN (1-770): 0: 562: 86.27		GSC_HUMAN (160-391): 9.22e-27: 109: 19.92
+	Hs
		980732 TLE3_HUMAN (1-770): 3.93e-176: 526: 77.42		HME1_HUMAN (1-392): 1.5e-35: 136: 100.00
+	Hs
		882122 TLE3_HUMAN (1-770): 3.93e-176: 526: 77.42		GSC_HUMAN (160-391): 9.22e-27: 109: 19.92
+	Dm
		558391 GROU_DROME (1-770): 7.74e-141: 433: 59.79		Q9NHP8_DROME (3-391): 2.9e-46: 167: 17.18
+	Dm
		403512 GROU_DROME (1-770): 7.74e-141: 433: 59.79		HMIN_DROME (265-386): 3.58e-45: 165: 60.27
+	Hs
		980676 TLE2_HUMAN (1-770): 2e-150: 458: 64.85		HME1_HUMAN (1-392): 1.5e-35: 136: 100.00
+	Hs
		980675 TLE2_HUMAN (1-770): 2e-150: 458: 64.85		EMX2_HUMAN (156-391): 2.59e-32: 123: 24.79
+	Dm
		367240 GROU_DROME (1-770): 7.74e-141: 433: 59.79		HMEN_DROME (221-391): 1.93e-32: 130: 50.58
+	Dm
		558357 GROU_DROME (1-770): 7.74e-141: 433: 59.79		VND_DROME (3-380): 8.25e-32: 129: 16.92
+	Dm
		558366 GROU_DROME (1-770): 7.74e-141: 433: 59.79		UBX_DROME (180-361): 8.35e-29: 117: 20.67
+	Dm
		558365 GROU_DROME (1-770): 7.74e-141: 433: 59.79		GSC_DROME (20-375): 8.36e-27: 112: 15.45
+	Hs
		985207 TLE5_HUMAN (1-200): 1.21e-91: 287: 64.50		HME1_HUMAN (1-392): 1.5e-35: 136: 100.00
+	Hs
		829834 TLE5_HUMAN (1-200): 1.21e-91: 287: 64.50		HXA1_HUMAN (140-376): 1.7e-32: 126: 21.99
+	Hs
		447242 TLE5_HUMAN (1-200): 1.21e-91: 287: 64.50		HXB5_HUMAN (196-366): 1.41e-31: 122: 28.07
+	Hs
		882124 TLE5_HUMAN (1-200): 1.21e-91: 287: 64.50		GSC_HUMAN (160-391): 9.22e-27: 109: 19.92