HitPredict

Interactor 1: TLE1 (Q04724)
Transducin-like enhancer protein 1 (E(Sp1) homolog) (Enhancer of split groucho-like protein 1) (ESG1)
Gene: TLE1

Interactor 2: HES1 (Q14469)
Transcription factor HES-1 (Class B basic helix-loop-helix protein 39) (bHLHb39) (Hairy and enhancer of split 1) (Hairy homolog) (Hairy-like protein) (hHL)
Gene: HES1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.84	0.60	0.711

Property	Details
Experiments	19321451, 33961781, 19956621, 24270405, 18611861
Identification Methods	affinity chromatography technology, pull down, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0010628 - positive regulation of gene expression GO:0045892 - negative regulation of DNA-templated transcription
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 770 Hs			1 280
+	Hs
		980671 TLE1_HUMAN (1-770): 0: 594: 100.00		HEY1_HUMAN (7-278): 1.4e-64: 206: 29.62
+	Hs
		980651 TLE1_HUMAN (1-770): 0: 594: 100.00		HES4_HUMAN (1-205): 1.7e-52: 172: 54.59
+	Hs
		980638 TLE1_HUMAN (1-770): 0: 594: 100.00		HES6_HUMAN (11-228): 1.12e-47: 160: 29.68
+	Hs
		980686 TLE2_HUMAN (1-770): 2e-150: 458: 64.85		HES1_HUMAN (1-280): 2.76e-97: 288: 100.00
+	Hs
		980948 TLE4_HUMAN (1-770): 0: 562: 86.27		HES6_HUMAN (11-228): 1.12e-47: 160: 29.68
+	Mm
		1143960 TLE1_MOUSE (1-770): 0: 563: 97.15		HES6_MOUSE (11-228): 2.62e-46: 156: 25.11
+	Hs
		980840 TLE3_HUMAN (1-770): 3.93e-176: 526: 77.42		HES6_HUMAN (11-228): 1.12e-47: 160: 29.68
+	Dm
		558377 GROU_DROME (1-770): 7.74e-141: 433: 59.79		DPN_DROME (30-243): 1.16e-54: 184: 42.13
+	Dm
		558369 GROU_DROME (1-770): 7.74e-141: 433: 59.79		ESM3_DROME (26-278): 6.31e-54: 176: 22.73
+	Dm
		558371 GROU_DROME (1-770): 7.74e-141: 433: 59.79		ESMC_DROME (22-163): 1.05e-52: 172: 34.03
+	Dm
		558370 GROU_DROME (1-770): 7.74e-141: 433: 59.79		ESMB_DROME (25-198): 1.08e-51: 169: 27.23
+	Dm
		525718 GROU_DROME (1-770): 7.74e-141: 433: 59.79		ESM7_DROME (24-163): 1.21e-48: 161: 32.86
+	Dm
		525743 GROU_DROME (1-770): 7.74e-141: 433: 59.79		ESM8_DROME (28-203): 2.3e-48: 160: 20.67
+	Dm
		558372 GROU_DROME (1-770): 7.74e-141: 433: 59.79		ESMD_DROME (28-190): 8.42e-48: 159: 29.76
+	Dm
		558399 GROU_DROME (1-770): 7.74e-141: 433: 59.79		Q9VJ16_DROME (21-264): 1.49e-44: 159: 27.31
+	Dm
		534341 GROU_DROME (1-770): 7.74e-141: 433: 59.79		HAIR_DROME (13-236): 2.15e-43: 152: 41.85
+	Dm
		558409 GROU_DROME (1-770): 7.74e-141: 433: 59.79		Q9VWX7_DROME (14-158): 6.05e-45: 150: 27.33
+	Dm
		525705 GROU_DROME (1-770): 7.74e-141: 433: 59.79		ESM5_DROME (17-203): 2.87e-41: 142: 21.39
+	Hs
		62468 TLE5_HUMAN (1-200): 1.21e-91: 287: 64.50		HELT_HUMAN (28-277): 6.1e-44: 151: 25.58
+	Hs
		421 TLE5_HUMAN (1-200): 1.21e-91: 287: 64.50		A0A087WSW0_HUMAN (2-277): 1.02e-42: 150: 20.50