HitPredict

Interactor 1: TLE1 (Q04724)
Transducin-like enhancer protein 1 (E(Sp1) homolog) (Enhancer of split groucho-like protein 1) (ESG1)
Gene: TLE1

Interactor 2: HES6 (Q96HZ4)
Transcription cofactor HES-6 (C-HAIRY1) (Class B basic helix-loop-helix protein 41) (bHLHb41) (Hairy and enhancer of split 6)
Gene: HES6

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.74	0.60	0.669

Property	Details
Experiments	11551980, 33961781, 20211142
Identification Methods	two hybrid, affinity chromatography technology, two hybrid array, anti tag coimmunoprecipitation
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005667 - transcription regulator complex
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 770 Hs			1 224
+	Hs
		980604 TLE1_HUMAN (1-770): 0: 594: 100.00		HES1_HUMAN (2-220): 9.41e-53: 172: 25.44
+	Hs
		980948 TLE4_HUMAN (1-770): 0: 562: 86.27		HES6_HUMAN (1-224): 2.14e-63: 198: 100.00
+	Mm
		1143960 TLE1_MOUSE (1-770): 0: 563: 97.15		HES6_MOUSE (1-224): 2.39e-60: 190: 85.71
+	Hs
		980671 TLE1_HUMAN (1-770): 0: 594: 100.00		HEY1_HUMAN (18-220): 3.7e-43: 149: 24.89
+	Hs
		980651 TLE1_HUMAN (1-770): 0: 594: 100.00		HES4_HUMAN (2-224): 2.93e-41: 141: 24.56
+	Hs
		980840 TLE3_HUMAN (1-770): 3.93e-176: 526: 77.42		HES6_HUMAN (1-224): 2.14e-63: 198: 100.00
+	Hs
		980686 TLE2_HUMAN (1-770): 2e-150: 458: 64.85		HES1_HUMAN (2-220): 9.41e-53: 172: 25.44
+	Dm
		558371 GROU_DROME (1-770): 7.74e-141: 433: 59.79		ESMC_DROME (11-224): 1.69e-46: 154: 25.79
+	Dm
		558377 GROU_DROME (1-770): 7.74e-141: 433: 59.79		DPN_DROME (18-219): 2.63e-43: 152: 28.57
+	Dm
		558369 GROU_DROME (1-770): 7.74e-141: 433: 59.79		ESM3_DROME (18-224): 2.62e-43: 147: 22.32
+	Dm
		558370 GROU_DROME (1-770): 7.74e-141: 433: 59.79		ESMB_DROME (18-224): 6.6e-41: 140: 20.72
+	Dm
		525718 GROU_DROME (1-770): 7.74e-141: 433: 59.79		ESM7_DROME (18-149): 1.41e-40: 139: 30.37
+	Dm
		558372 GROU_DROME (1-770): 7.74e-141: 433: 59.79		ESMD_DROME (11-149): 5.7e-36: 126: 28.08
+	Dm
		534341 GROU_DROME (1-770): 7.74e-141: 433: 59.79		HAIR_DROME (23-204): 1.45e-33: 124: 26.90
+	Dm
		525705 GROU_DROME (1-770): 7.74e-141: 433: 59.79		ESM5_DROME (9-224): 9.82e-35: 123: 18.64
+	Dm
		525743 GROU_DROME (1-770): 7.74e-141: 433: 59.79		ESM8_DROME (19-174): 7.31e-35: 123: 22.02
+	Dm
		558409 GROU_DROME (1-770): 7.74e-141: 433: 59.79		Q9VWX7_DROME (5-139): 5.74e-35: 123: 22.07
+	Dm
		558399 GROU_DROME (1-770): 7.74e-141: 433: 59.79		Q9VJ16_DROME (12-216): 1.63e-31: 122: 19.91
+	Hs
		62468 TLE5_HUMAN (1-200): 1.21e-91: 287: 64.50		HELT_HUMAN (16-208): 2.52e-37: 132: 26.64
+	Hs
		421 TLE5_HUMAN (1-200): 1.21e-91: 287: 64.50		A0A087WSW0_HUMAN (2-208): 2.71e-32: 121: 21.69