HitPredict

Interactor 1: TLE2 (Q04725)
Transducin-like enhancer protein 2 (Enhancer of split groucho-like protein 2) (ESG2)
Gene: TLE2

Interactor 2: LEF1 (Q9UJU2)
Lymphoid enhancer-binding factor 1 (LEF-1) (T cell-specific transcription factor 1-alpha) (TCF1-alpha)
Gene: LEF1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.60	0.501

Property	Details
Experiments	15768032
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005667 - transcription regulator complex GO:0045892 - negative regulation of DNA-templated transcription
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 743 Hs			1 399
+	Hs
		980665 TLE1_HUMAN (1-743): 2.32e-174: 520: 65.46		LEF1_HUMAN (1-399): 1.07e-102: 311: 100.00
+	Mm
		653462 TLE4_MOUSE (1-743): 1.35e-176: 526: 65.93		LEF1_MOUSE (1-399): 6.56e-99: 301: 97.24
+	Hs
		980882 TLE3_HUMAN (1-743): 2.94e-166: 499: 63.91		TF7L2_HUMAN (22-387): 1.66e-58: 202: 51.88
+	Hs
		727732 TLE1_HUMAN (1-743): 2.32e-174: 520: 65.46		SOX5_HUMAN (123-374): 1.28e-33: 134: 16.22
+	Hs
		881797 TLE1_HUMAN (1-743): 2.32e-174: 520: 65.46		SOX10_HUMAN (254-397): 1.63e-33: 132: 20.83
+	Hs
		818792 TLE1_HUMAN (1-743): 2.32e-174: 520: 65.46		SOX9_HUMAN (198-390): 6.63e-33: 130: 19.07
+	Hs
		817954 TLE1_HUMAN (1-743): 2.32e-174: 520: 65.46		SOX2_HUMAN (272-396): 2.2e-32: 126: 22.40
+	Hs
		980847 TLE3_HUMAN (1-743): 2.94e-166: 499: 63.91		CIC_HUMAN (63-393): 8.23e-35: 138: 16.47
+	Dm
		558368 GROU_DROME (1-743): 8.48e-144: 440: 54.69		PANG1_DROME (1-393): 1.68e-54: 194: 37.62
+	Hs
		817955 TLE3_HUMAN (1-743): 2.94e-166: 499: 63.91		SOX2_HUMAN (272-396): 2.2e-32: 126: 22.40
+	Hs
		727850 TLE1_HUMAN (1-743): 2.32e-174: 520: 65.46		SOX6_HUMAN (287-369): 2.63e-23: 104: 30.12
+	Dm
		558384 GROU_DROME (1-743): 8.48e-144: 440: 54.69		PANG2_DROME (49-393): 5.03e-50: 183: 31.05
+	Hs
		727851 TLE3_HUMAN (1-743): 2.94e-166: 499: 63.91		SOX6_HUMAN (287-369): 2.63e-23: 104: 30.12
+	Dm
		558375 GROU_DROME (1-743): 8.48e-144: 440: 54.69		DICH_DROME (172-394): 2.2e-29: 119: 18.72
+	Ce
		137672 UNC37_CAEEL (17-743): 8.34e-127: 392: 35.01		POP1_CAEEL (191-372): 4.4e-37: 141: 30.24
+	Dm
		558392 GROU_DROME (1-743): 8.48e-144: 440: 54.69		CIC_DROME (299-397): 3.47e-19: 91.9: 30.30
+	Hs
		993616 TLE5_HUMAN (1-185): 8.53e-92: 286: 62.89		TF7L2_HUMAN (22-387): 1.66e-58: 202: 51.88
+	Hs
		727734 TLE5_HUMAN (1-185): 8.53e-92: 286: 62.89		SOX5_HUMAN (123-374): 1.28e-33: 134: 16.22
+	Hs
		817967 TLE5_HUMAN (1-185): 8.53e-92: 286: 62.89		SOX2_HUMAN (272-396): 2.2e-32: 126: 22.40
+	Hs
		178916 TLE5_HUMAN (1-185): 8.53e-92: 286: 62.89		TOX3_HUMAN (132-370): 1.01e-28: 119: 10.88