HitPredict

Interactor 1: TLE4 (Q04727)
Transducin-like enhancer protein 4 (Grg-4) (Groucho-related protein 4)
Gene: TLE4

Interactor 2: HME1 (Q05925)
Homeobox protein engrailed-1 (Homeobox protein en-1) (Hu-En-1)
Gene: EN1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	0.60	0.628

Property	Details
Experiments	33961781, 35140242
Identification Methods	affinity chromatography technology, proximity labelling technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0005634 - nucleus
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 773 Hs			1 392
+	Hs
		882123 TLE4_HUMAN (1-773): 0: 622: 100.00		GSC_HUMAN (160-391): 9.22e-27: 109: 19.92
+	Hs
		980587 TLE1_HUMAN (8-773): 0: 580: 86.27		HME1_HUMAN (1-392): 1.5e-35: 136: 100.00
+	Hs
		829830 TLE1_HUMAN (8-773): 0: 580: 86.27		HXA1_HUMAN (140-376): 1.7e-32: 126: 21.99
+	Hs
		585946 TLE1_HUMAN (8-773): 0: 580: 86.27		HME2_HUMAN (44-392): 3.87e-26: 109: 42.98
+	Hs
		882121 TLE1_HUMAN (8-773): 0: 580: 86.27		GSC_HUMAN (160-391): 9.22e-27: 109: 19.92
+	Hs
		980663 TLE1_HUMAN (8-773): 0: 580: 86.27		HESX1_HUMAN (232-375): 1.5e-27: 109: 26.39
+	Hs
		980732 TLE3_HUMAN (8-773): 0: 539: 80.90		HME1_HUMAN (1-392): 1.5e-35: 136: 100.00
+	Hs
		882122 TLE3_HUMAN (8-773): 0: 539: 80.90		GSC_HUMAN (160-391): 9.22e-27: 109: 19.92
+	Hs
		980676 TLE2_HUMAN (8-773): 3.63e-157: 476: 65.19		HME1_HUMAN (1-392): 1.5e-35: 136: 100.00
+	Dm
		558391 GROU_DROME (8-773): 1.23e-144: 443: 59.14		Q9NHP8_DROME (3-391): 2.9e-46: 167: 17.18
+	Dm
		403512 GROU_DROME (8-773): 1.23e-144: 443: 59.14		HMIN_DROME (265-386): 3.58e-45: 165: 60.27
+	Hs
		980675 TLE2_HUMAN (8-773): 3.63e-157: 476: 65.19		EMX2_HUMAN (156-391): 2.59e-32: 123: 24.79
+	Dm
		367240 GROU_DROME (8-773): 1.23e-144: 443: 59.14		HMEN_DROME (221-391): 1.93e-32: 130: 50.58
+	Dm
		558357 GROU_DROME (8-773): 1.23e-144: 443: 59.14		VND_DROME (3-380): 8.25e-32: 129: 16.92
+	Dm
		558366 GROU_DROME (8-773): 1.23e-144: 443: 59.14		UBX_DROME (180-361): 8.35e-29: 117: 20.67
+	Dm
		558365 GROU_DROME (8-773): 1.23e-144: 443: 59.14		GSC_DROME (20-375): 8.36e-27: 112: 15.45
+	Ce
		137666 UNC37_CAEEL (24-773): 5.04e-95: 310: 36.86		HM16_CAEEL (254-364): 7.96e-38: 136: 57.27
+	Ce
		108144 UNC37_CAEEL (24-773): 5.04e-95: 310: 36.86		G5EGE2_CAEEL (285-368): 2.26e-30: 118: 35.96
+	Ce
		137665 UNC37_CAEEL (24-773): 5.04e-95: 310: 36.86		UNC4_CAEEL (244-386): 4.77e-28: 112: 20.55
+	Ce
		137664 UNC37_CAEEL (24-773): 5.04e-95: 310: 36.86		HM19_CAEEL (293-378): 1.9e-27: 109: 34.88