HitPredict

Interactor 1: EMX1 (Q04742)
Homeobox protein EMX1 (Empty spiracles homolog 1) (Empty spiracles-like protein 1)
Gene: EMX1

Interactor 2: Q8R0B5 (Q8R0B5)
Orthodenticle homeobox 2 (Otx2 protein)
Gene: Otx2

Species: Mus musculus

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.34	1.00	0.590

Property	Details
Experiments	20211142
Identification Methods	two hybrid array
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Homeodomain~Homeodomain
Common GO terms	GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0005634 - nucleus
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 257 Mm			1 297
+	Mm
		980982 EMX1_MOUSE (1-257): 9.25e-55: 178: 100.00		Q8VD35_MOUSE (1-297): 3.5e-76: 235: 97.31
+	Hs
		980974 EMX1_HUMAN (1-257): 8.4e-51: 169: 96.50		ALX4_HUMAN (21-245): 3.1e-34: 130: 23.79
+	Dm
		185933 Q7KS72_DROME (68-231): 2.74e-44: 154: 32.32		PITX_DROME (22-277): 2.5e-34: 132: 21.79
+	Dm
		987396 Q7KS72_DROME (68-231): 2.74e-44: 154: 32.32		AL_DROME (10-253): 6.33e-35: 132: 24.50
+	Dm
		987400 Q9VD99_DROME (68-231): 7.56e-44: 151: 32.32		AL_DROME (10-253): 6.33e-35: 132: 24.50
+	Dm
		668320 ABDA_DROME (100-231): 1.8e-34: 132: 27.27		Q9XZU0_DROME (37-289): 7.39e-39: 141: 25.98
+	Dm
		415559 ABDA_DROME (100-231): 1.8e-34: 132: 27.27		PRD_DROME (2-263): 1.54e-36: 139: 27.55
+	Dm
		447431 ABDA_DROME (100-231): 1.8e-34: 132: 27.27		GSBN_DROME (41-229): 1.15e-36: 137: 29.63
+	Hs
		538719 HXB2_HUMAN (93-248): 1.96e-35: 131: 29.73		HXB2_HUMAN (1-270): 1.35e-36: 135: 21.11
+	Hs
		620232 MSX1_HUMAN (36-231): 2.05e-33: 124: 32.16		PAX3_HUMAN (20-276): 8.85e-38: 141: 25.48
+	Dm
		185925 ABDA_DROME (100-231): 1.8e-34: 132: 27.27		PITX_DROME (22-277): 2.5e-34: 132: 21.79
+	Dm
		668243 ABDA_DROME (100-231): 1.8e-34: 132: 27.27		AL_DROME (10-253): 6.33e-35: 132: 24.50
+	Hs
		238103 HXA1_HUMAN (3-232): 6.59e-32: 121: 23.48		LMX1B_HUMAN (8-237): 2.13e-38: 141: 18.97
+	Hs
		829821 HXA1_HUMAN (3-232): 6.59e-32: 121: 23.48		PITX1_HUMAN (40-228): 2.22e-39: 141: 31.68
+	Hs
		1077278 ALX1_HUMAN (34-250): 2.62e-35: 130: 18.89		ALX4_HUMAN (21-245): 3.1e-34: 130: 23.79
+	Hs
		678782 HXD3_HUMAN (99-240): 2.84e-34: 129: 26.06		ALX4_HUMAN (21-245): 3.1e-34: 130: 23.79
+	Hs
		641341 HXA1_HUMAN (3-232): 6.59e-32: 121: 23.48		PAX6_HUMAN (7-258): 2.43e-36: 136: 25.00
+	Hs
		686412 HXA1_HUMAN (3-232): 6.59e-32: 121: 23.48		OTX1_HUMAN (1-297): 5.86e-36: 133: 43.96
+	Dm
		668312 ABDA_DROME (100-231): 1.8e-34: 132: 27.27		Q9W1H7_DROME (42-142): 1.88e-32: 121: 40.78
+	Dm
		48151 ABDA_DROME (100-231): 1.8e-34: 132: 27.27		A0AVV3_DROME (44-111): 1.19e-16: 82: 59.46