HitPredict

Interactor 1: REL (Q04864)
Proto-oncogene c-Rel
Gene: REL

Interactor 2: IKBB (Q15653)
NF-kappa-B inhibitor beta (NF-kappa-BIB) (I-kappa-B-beta) (IkB-B) (IkB-beta) (IkappaBbeta) (Thyroid receptor-interacting protein 9) (TR-interacting protein 9) (TRIP-9)
Gene: NFKBIB

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.93	1.00	0.969

Property	Details
Experiments	27609421, 10706725, 8887627, 26186194, 28514442, 33961781, 14743216, 9135156, 16226509
Identification Methods	affinity chromatography technology, tandem affinity purification, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Ank~RHD_dimer, Ank_2~RHD_dimer
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol GO:0006954 - inflammatory response
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 619 Hs			1 356
+	Hs
		639734 REL_HUMAN (1-619): 0: 692: 100.00		IKBA_HUMAN (14-335): 5.39e-78: 243: 30.21
+	Hs
		961369 REL_HUMAN (1-619): 0: 692: 100.00		NFKB2_HUMAN (35-347): 1.91e-71: 240: 31.15
+	Hs
		121586 REL_HUMAN (1-619): 0: 692: 100.00		IKBE_HUMAN (25-333): 1.22e-60: 204: 31.72
+	Mm
		546808 REL_MOUSE (1-619): 0: 628: 70.19		IKBB_MOUSE (1-355): 1.52e-80: 251: 83.52
+	Mm
		546810 REL_MOUSE (1-619): 0: 628: 70.19		IKBA_MOUSE (7-335): 8.92e-77: 240: 31.07
+	Hs
		587543 REL_HUMAN (1-619): 0: 692: 100.00		NFKB1_HUMAN (28-140): 2.07e-10: 64.4: 29.57
+	Mm
		978962 TF65_MOUSE (2-576): 1.99e-167: 490: 38.89		IKBB_MOUSE (1-355): 1.52e-80: 251: 83.52
+	Mm
		978991 TF65_MOUSE (2-576): 1.99e-167: 490: 38.89		IKBA_MOUSE (7-335): 8.92e-77: 240: 31.07
+	Rn
		1144369 Q7TQN4_RAT (2-576): 2.12e-167: 490: 38.48		IKBA_RAT (7-335): 3.8e-76: 238: 30.77
+	Mm
		978989 TF65_MOUSE (2-576): 1.99e-167: 490: 38.89		NFKB2_MOUSE (55-347): 8.38e-68: 230: 33.11
+	Hs
		978766 TF65_HUMAN (2-576): 4.74e-158: 466: 37.89		IKBB_HUMAN (1-356): 9.91e-80: 249: 100.00
+	Hs
		639733 TF65_HUMAN (2-576): 4.74e-158: 466: 37.89		IKBA_HUMAN (14-335): 5.39e-78: 243: 30.21
+	Hs
		961368 TF65_HUMAN (2-576): 4.74e-158: 466: 37.89		NFKB2_HUMAN (35-347): 1.91e-71: 240: 31.15
+	Mm
		222601 TF65_MOUSE (2-576): 1.99e-167: 490: 38.89		IKBE_MOUSE (51-333): 1.19e-64: 211: 32.86
+	Mm
		638473 NFKB1_MOUSE (1-414): 1.82e-152: 465: 33.56		NFKB2_MOUSE (55-347): 8.38e-68: 230: 33.11
+	Mm
		546805 REL_MOUSE (1-619): 0: 628: 70.19		NFKB1_MOUSE (14-140): 5.94e-11: 65.9: 29.46
+	Hs
		121585 TF65_HUMAN (2-576): 4.74e-158: 466: 37.89		IKBE_HUMAN (25-333): 1.22e-60: 204: 31.72
+	Mm
		638449 TF65_MOUSE (2-576): 1.99e-167: 490: 38.89		NFKB1_MOUSE (14-140): 5.94e-11: 65.9: 29.46
+	Mm
		638435 NFKB1_MOUSE (1-414): 1.82e-152: 465: 33.56		NFKB1_MOUSE (14-140): 5.94e-11: 65.9: 29.46
+	Hs
		587542 TF65_HUMAN (2-576): 4.74e-158: 466: 37.89		NFKB1_HUMAN (28-140): 2.07e-10: 64.4: 29.57