HitPredict

Interactor 1: SOX8 (Q04886)
Transcription factor SOX-8
Gene: SOX8

Interactor 2: PRRX2 (Q06348)
Paired mesoderm homeobox protein 2 (PRX-2) (Homeobox protein S8)
Gene: PRRX2

Species: Mus musculus

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.481

Property	Details
Experiments	16582099
Identification Methods	two hybrid
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific GO:0005634 - nucleus GO:0045944 - positive regulation of transcription by RNA polymerase II
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 464 Mm			1 247
+	Mm
		926104 SOX8_MOUSE (1-464): 7.47e-66: 220: 100.00		PRRX1_MOUSE (2-247): 5.68e-38: 134: 53.23
+	Mm
		623697 SOX8_MOUSE (1-464): 7.47e-66: 220: 100.00		PAX3_MOUSE (72-244): 2.1e-30: 119: 32.95
+	Hs
		1300967 CIC_HUMAN (30-341): 1.13e-35: 143: 18.89		VSX1_HUMAN (38-211): 1.13e-38: 139: 32.39
+	Hs
		174010 SOX6_HUMAN (32-302): 2.1e-39: 153: 24.13		SHOX_HUMAN (82-160): 1.44e-33: 124: 59.49
+	Ce
		1093676 SOX3_CAEEL (61-227): 8.54e-43: 152: 33.92		HM30_CAEEL (6-232): 1.58e-32: 120: 23.48
+	Hs
		238117 CIC_HUMAN (30-341): 1.13e-35: 143: 18.89		LMX1B_HUMAN (54-240): 8.21e-34: 127: 24.87
+	Hs
		620239 SOX10_HUMAN (7-464): 6.89e-40: 151: 40.90		PAX3_HUMAN (72-244): 1.6e-30: 119: 32.37
+	Hs
		641534 CIC_HUMAN (30-341): 1.13e-35: 143: 18.89		PAX6_HUMAN (52-245): 2.14e-33: 126: 30.46
+	Hs
		620250 CIC_HUMAN (30-341): 1.13e-35: 143: 18.89		PAX3_HUMAN (72-244): 1.6e-30: 119: 32.37
+	Hs
		641570 HM20A_HUMAN (1-204): 2.32e-35: 136: 13.94		PAX6_HUMAN (52-245): 2.14e-33: 126: 30.46
+	Hs
		641616 CABIN_HUMAN (20-419): 1.54e-33: 136: 10.44		PAX6_HUMAN (52-245): 2.14e-33: 126: 30.46
+	Mm
		192288 SOX15_MOUSE (99-203): 5.4e-38: 140: 52.29		ALX4_MOUSE (14-238): 1.29e-31: 121: 25.53
+	Hs
		839810 CIC_HUMAN (30-341): 1.13e-35: 143: 18.89		LHX2_HUMAN (35-240): 2.72e-30: 118: 22.71
+	Hs
		882171 SOX13_HUMAN (94-175): 1.34e-34: 138: 47.56		GSC_HUMAN (3-180): 1.2e-32: 121: 29.32
+	Hs
		641331 SOX5_HUMAN (80-176): 1.1e-31: 130: 42.27		PAX6_HUMAN (52-245): 2.14e-33: 126: 30.46
+	Hs
		174009 SOX5_HUMAN (80-176): 1.1e-31: 130: 42.27		SHOX_HUMAN (82-160): 1.44e-33: 124: 59.49
+	Hs
		727714 SOX5_HUMAN (80-176): 1.1e-31: 130: 42.27		GSC_HUMAN (3-180): 1.2e-32: 121: 29.32
+	Dm
		58608 DICH_DROME (88-326): 7.83e-32: 127: 28.87		A2RVG7_DROME (39-243): 7.55e-31: 117: 27.81
+	Hs
		620192 CIC_HUMAN (30-341): 1.13e-35: 143: 18.89		PAX7_HUMAN (95-159): 4.82e-18: 84.7: 64.62
+	Hs
		620210 HM20A_HUMAN (1-204): 2.32e-35: 136: 13.94		PAX7_HUMAN (95-159): 4.82e-18: 84.7: 64.62