HitPredict

Interactor 1: SOX8 (Q04886)
Transcription factor SOX-8
Gene: SOX8

Interactor 2: Q60I23 (Q60I23)
SRY (sex determining region Y)-box 2 (Sox2 protein) (Transcriptional factor SOX2)
Gene: Sox2

Species: Mus musculus

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	1.00	0.575

Property	Details
Experiments	21532573
Identification Methods	anti tag coimmunoprecipitation
Interaction Type	association

Property	Details
Interacting Pfam domains	HMG_box~HMG_box
Common GO terms	GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0001649 - osteoblast differentiation
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 464 Mm			1 319
+	Hs
		817845 SOX8_HUMAN (1-464): 1.26e-49: 177: 76.66		SOX2_HUMAN (1-319): 1.7e-62: 202: 96.24
+	Hs
		727836 SOX6_HUMAN (32-302): 2.1e-39: 153: 24.13		SOX2_HUMAN (1-319): 1.7e-62: 202: 96.24
+	Hs
		727705 SOX6_HUMAN (32-302): 2.1e-39: 153: 24.13		SOX5_HUMAN (17-129): 1.06e-39: 150: 40.71
+	Dm
		1212946 PANG2_DROME (41-447): 3.17e-42: 162: 15.22		PANG2_DROME (11-278): 1.89e-35: 137: 14.07
+	Mm
		727702 SOX6_MOUSE (32-302): 1.36e-37: 148: 24.13		SOX5_MOUSE (17-129): 1.42e-39: 149: 40.71
+	Hs
		727706 SOX11_HUMAN (55-185): 4.35e-38: 145: 40.15		SOX5_HUMAN (17-129): 1.06e-39: 150: 40.71
+	Hs
		727910 SOX6_HUMAN (32-302): 2.1e-39: 153: 24.13		CIC_HUMAN (10-274): 1.46e-36: 141: 24.28
+	Hs
		881826 SOX10_HUMAN (7-464): 6.89e-40: 151: 40.90		CIC_HUMAN (10-274): 1.46e-36: 141: 24.28
+	Hs
		1300941 SOX17_HUMAN (96-322): 1.43e-37: 143: 34.03		CIC_HUMAN (10-274): 1.46e-36: 141: 24.28
+	Hs
		881814 SOX10_HUMAN (7-464): 6.89e-40: 151: 40.90		PB1_HUMAN (8-232): 6.76e-34: 133: 14.67
+	Hs
		297488 TOX4_HUMAN (5-407): 3.48e-42: 159: 12.21		SSRP1_HUMAN (21-210): 1.09e-30: 124: 15.71
+	Dm
		1212959 PANG2_DROME (41-447): 3.17e-42: 162: 15.22		Q9VUD3_DROME (13-215): 8.92e-30: 120: 41.38
+	Hs
		1199196 SOX17_HUMAN (96-322): 1.43e-37: 143: 34.03		PB1_HUMAN (8-232): 6.76e-34: 133: 14.67
+	Hs
		297438 TOX4_HUMAN (5-407): 3.48e-42: 159: 12.21		TOX4_HUMAN (9-316): 7.19e-28: 115: 12.14
+	Hs
		297441 TOX4_HUMAN (5-407): 3.48e-42: 159: 12.21		NSD2_HUMAN (1-250): 1.25e-27: 115: 11.83
+	Hs
		727933 SOX6_HUMAN (32-302): 2.1e-39: 153: 24.13		HM20B_HUMAN (6-159): 4.8e-28: 112: 23.38
+	Dm
		114457 M9PCG2_DROME (74-213): 1.69e-36: 143: 40.41		PANG1_DROME (19-278): 9.74e-29: 118: 14.50
+	Hs
		881788 SOX10_HUMAN (7-464): 6.89e-40: 151: 40.90		SOX10_HUMAN (27-318): 1.19e-26: 110: 24.35