HitPredict

Interactor 1: PSMD3 (Q04908)
26S proteasome non-ATPase regulatory subunit 3 (26S proteasome regulatory subunit rpn-3)
Gene: rpn-3

Interactor 2: PSMD6 (Q20585)
26S proteasome non-ATPase regulatory subunit 6 (26S proteasome regulatory subunit rpn-7)
Gene: rpn-7

Species: Caenorhabditis elegans

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.67	0.80	0.733

Property	Details
Experiments	12679813, 14704431, 11559592
Identification Methods	two hybrid, two hybrid pooling approach
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	PCI~PCI, PCI~RPN7, PCI~Rpn3_C
Common GO terms	-
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 504 Ce			1 410
+	Hs
		198630 PSMD3_HUMAN (14-504): 0: 530: 43.66		PSMD6_HUMAN (16-409): 3.19e-126: 371: 46.70
+	Dm
		627131 PSMD3_DROME (12-504): 1.31e-180: 517: 42.37		PSMD6_DROME (15-409): 1.63e-119: 354: 46.84
+	Sp
		194818 RPN3_SCHPO (10-503): 3e-171: 493: 36.90		RPN7_SCHPO (21-408): 5.1e-106: 320: 37.76
+	Hs
		121636 PSMD3_HUMAN (14-504): 0: 530: 43.66		PSD11_HUMAN (41-410): 1.23e-75: 243: 12.95
+	Dm
		627126 PSMD3_DROME (12-504): 1.31e-180: 517: 42.37		PSD11_DROME (19-410): 2.39e-77: 247: 13.83
+	Sc
		766888 RPN3_YEAST (13-502): 1.2e-158: 462: 29.18		RPN7_YEAST (23-408): 1.01e-94: 292: 31.70
+	Mm
		102341 CSN3_MOUSE (185-466): 1.09e-86: 274: 15.23		G3UXW9_MOUSE (22-404): 1.59e-101: 313: 20.56
+	Mm
		291850 CSN3_MOUSE (185-466): 1.09e-86: 274: 15.23		CSN1_MOUSE (22-404): 1.93e-100: 308: 20.56
+	At
		799474 CSN3_ARATH (222-458): 2.27e-77: 250: 20.66		CSN1_ARATH (6-404): 9.09e-107: 323: 20.73
+	Hs
		1024241 CSN3_HUMAN (185-466): 2.69e-86: 273: 15.23		CSN1_HUMAN (22-404): 3.6e-96: 298: 19.60
+	Mm
		291845 CSN3_MOUSE (185-466): 1.09e-86: 274: 15.23		CSN2_MOUSE (18-410): 3.24e-93: 288: 11.94
+	Sc
		766899 RPN3_YEAST (13-502): 1.2e-158: 462: 29.18		RPN6_YEAST (192-409): 4.31e-22: 99.4: 15.63
+	Hs
		897331 CSN3_HUMAN (185-466): 2.69e-86: 273: 15.23		CSN2_HUMAN (18-410): 3.24e-93: 288: 11.94
+	At
		1258865 CSN3_ARATH (222-458): 2.27e-77: 250: 20.66		CSN2_ARATH (15-410): 2.75e-88: 276: 12.07
+	Ce
		136319 CSN3_CAEEL (245-420): 5.15e-44: 164: 11.54		CSN2_CAEEL (18-383): 6.42e-82: 261: 11.38
+	Ce
		1325700 CSN3_CAEEL (245-420): 5.15e-44: 164: 11.54		CSN1_CAEEL (22-404): 3.78e-78: 254: 15.73