HitPredict

Interactor 1: 1433F (Q04917)
14-3-3 protein eta (Protein AS1)
Gene: YWHAH

Interactor 2: SPIR1 (Q08AE8)
Protein spire homolog 1 (Spir-1)
Gene: SPIRE1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.73	0.60	0.662

Property	Details
Experiments	33961781, 36931259, 28514442
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003779 - actin binding GO:0005829 - cytosol GO:0005886 - plasma membrane
Homologous interactions	13

Homologous interactions

Color coding for hit scores

	1 246 Hs			1 756
+	Hs
		909483 1433E_HUMAN (1-244): 1.37e-141: 398: 62.71		SPIR1_HUMAN (12-756): 0: 1109: 100.00
+	Hs
		904492 1433G_HUMAN (1-246): 9.38e-138: 388: 86.99		SPIR1_HUMAN (12-756): 0: 1109: 100.00
+	Hs
		926970 1433Z_HUMAN (3-245): 1.27e-107: 312: 74.49		SPIR1_HUMAN (12-756): 0: 1109: 100.00
+	Hs
		683296 1433B_HUMAN (3-245): 2.7e-107: 311: 75.51		SPIR1_HUMAN (12-756): 0: 1109: 100.00
+	Hs
		646836 1433T_HUMAN (3-245): 7.19e-106: 307: 71.43		SPIR1_HUMAN (12-756): 0: 1109: 100.00
+	Hs
		683996 1433S_HUMAN (3-245): 2.76e-96: 283: 64.20		SPIR1_HUMAN (12-756): 0: 1109: 100.00
+	Hs
		909861 1433E_HUMAN (1-244): 1.37e-141: 398: 62.71		SPIR2_HUMAN (40-738): 0: 884: 41.39
+	Hs
		904918 1433G_HUMAN (1-246): 9.38e-138: 388: 86.99		SPIR2_HUMAN (40-738): 0: 884: 41.39
+	Hs
		982329 1433F_HUMAN (1-246): 6.09e-136: 383: 100.00		SPIR2_HUMAN (40-738): 0: 884: 41.39
+	Hs
		927345 1433Z_HUMAN (3-245): 1.27e-107: 312: 74.49		SPIR2_HUMAN (40-738): 0: 884: 41.39
+	Hs
		683577 1433B_HUMAN (3-245): 2.7e-107: 311: 75.51		SPIR2_HUMAN (40-738): 0: 884: 41.39
+	Hs
		647143 1433T_HUMAN (3-245): 7.19e-106: 307: 71.43		SPIR2_HUMAN (40-738): 0: 884: 41.39
+	Hs
		684236 1433S_HUMAN (3-245): 2.76e-96: 283: 64.20		SPIR2_HUMAN (40-738): 0: 884: 41.39