HitPredict

Interactor 1: UBE3A (Q05086)
Ubiquitin-protein ligase E3A (EC 2.3.2.26) (E6AP ubiquitin-protein ligase) (HECT-type ubiquitin transferase E3A) (Human papillomavirus E6-associated protein) (Oncogenic protein-associated protein E6-AP) (Renal carcinoma antigen NY-REN-54)
Gene: UBE3A

Interactor 2: UBE3A (Q05086)
Ubiquitin-protein ligase E3A (EC 2.3.2.26) (E6AP ubiquitin-protein ligase) (HECT-type ubiquitin transferase E3A) (Human papillomavirus E6-associated protein) (Oncogenic protein-associated protein E6-AP) (Renal carcinoma antigen NY-REN-54)
Gene: UBE3A

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.98 1.00 0.990

The method score is based on:

Property Details
Experiments 26506232, 26216987, 17426036, 15263005, 23695783, 28292943, 29263404, 22645313, 29511261, 30254168, 30361475, 31492752, 31329371, 35025136, 35045253, 36114200, 30920720, 9688277, 21033666, 15331633 and 4 others

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Identification Methods pull down, enzymatic study, affinity chromatography technology, x-ray crystallography
Interaction Type direct interaction, physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains HECT~HECT
Common GO terms GO:0000209 - protein polyubiquitination
GO:0000502 - proteasome complex
GO:0001541 - ovarian follicle development
GO:0003713 - transcription coactivator activity
GO:0004842 - ubiquitin-protein transferase activity
and 31 others

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Homologous interactions 16

Homologous interactions

Color coding for hit scores

1 875
Hs

1 875
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Service provided by Combinatics, Japan

Last updated: 15 Jul 2024