HitPredict

Interactor 1: UBE3A (Q05086)
Ubiquitin-protein ligase E3A (EC 2.3.2.26) (E6AP ubiquitin-protein ligase) (HECT-type ubiquitin transferase E3A) (Human papillomavirus E6-associated protein) (Oncogenic protein-associated protein E6-AP) (Renal carcinoma antigen NY-REN-54)
Gene: UBE3A

Interactor 2: ECH1 (Q13011)
Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial (EC 5.3.3.-)
Gene: ECH1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.611

Property	Details
Experiments	22645313, 29426014
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 875 Hs			1 328
+	Hs
		267397 UBE3A_HUMAN (1-875): 0: 1058: 100.00		ECI2_HUMAN (45-319): 4.15e-76: 240: 20.73
+	Hs
		1022579 ITCH_HUMAN (325-873): 0: 579: 24.78		ECH1_HUMAN (1-328): 2.81e-109: 322: 100.00
+	Hs
		671526 SMUF2_HUMAN (334-872): 0: 554: 24.79		ECHM_HUMAN (27-322): 3.57e-91: 275: 24.66
+	Hs
		267435 ITCH_HUMAN (325-873): 0: 579: 24.78		ECI2_HUMAN (45-319): 4.15e-76: 240: 20.73
+	Hs
		125210 WWP2_HUMAN (291-873): 0: 589: 24.72		ECHA_HUMAN (70-246): 5.11e-15: 77.8: 31.87
+	Hs
		1022529 HUWE1_HUMAN (523-874): 5.96e-53: 203: 33.97		ECH1_HUMAN (1-328): 2.81e-109: 322: 100.00
+	Hs
		1192126 HUWE1_HUMAN (523-874): 5.96e-53: 203: 33.97		CDYL2_HUMAN (59-318): 3.5e-66: 218: 20.69