HitPredict

Interactor 1: UBE3A (Q05086)
Ubiquitin-protein ligase E3A (EC 2.3.2.26) (E6AP ubiquitin-protein ligase) (HECT-type ubiquitin transferase E3A) (Human papillomavirus E6-associated protein) (Oncogenic protein-associated protein E6-AP) (Renal carcinoma antigen NY-REN-54)
Gene: UBE3A

Interactor 2: ACTBL (Q562R1)
Beta-actin-like protein 2 (Kappa-actin)
Gene: ACTBL2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.73	0.60	0.664

Property	Details
Experiments	26506232, 29426014, 31329371
Identification Methods	pull down, affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0098978 - glutamatergic synapse
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 875 Hs			1 376
+	Hs
		891709 UBE3A_HUMAN (1-875): 0: 1058: 100.00		ACTB_HUMAN (3-376): 0: 596: 91.71
+	Hs
		932963 UBE3A_HUMAN (1-875): 0: 1058: 100.00		ACTS_HUMAN (2-376): 0: 590: 87.47
+	Hs
		915366 UBE3A_HUMAN (1-875): 0: 1058: 100.00		ACTA_HUMAN (1-376): 0: 588: 87.80
+	Hs
		1164377 SMUF1_HUMAN (405-872): 1.32e-175: 528: 27.04		POTEE_HUMAN (3-376): 0: 693: 85.03
+	Hs
		125356 WWP2_HUMAN (291-873): 0: 589: 24.72		ACTG_HUMAN (3-376): 0: 595: 91.44
+	Hs
		933057 SMUF2_HUMAN (334-872): 0: 554: 24.79		ACTS_HUMAN (2-376): 0: 590: 87.47
+	Hs
		915510 SMUF2_HUMAN (334-872): 0: 554: 24.79		ACTA_HUMAN (1-376): 0: 588: 87.80
+	Sc
		765355 RSP5_YEAST (310-873): 0: 554: 25.85		ACT_YEAST (1-376): 0: 585: 82.98
+	Hs
		892096 HERC5_HUMAN (153-873): 1.77e-175: 536: 23.20		ACTB_HUMAN (3-376): 0: 596: 91.71
+	Hs
		892047 SMUF1_HUMAN (405-872): 1.32e-175: 528: 27.04		ACTB_HUMAN (3-376): 0: 596: 91.71