HitPredict

Interactor 1: UBE3A (Q05086)
Ubiquitin-protein ligase E3A (EC 2.3.2.26) (E6AP ubiquitin-protein ligase) (HECT-type ubiquitin transferase E3A) (Human papillomavirus E6-associated protein) (Oncogenic protein-associated protein E6-AP) (Renal carcinoma antigen NY-REN-54)
Gene: UBE3A

Interactor 2: Q5U5U6 (Q5U5U6)
Epididymis secretory protein Li 50 (Ubiquitin B)
Gene: UBB

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.44	1.00	0.665

Property	Details
Experiments	25416956
Identification Methods	two hybrid prey pooling approach, two hybrid array, validated two hybrid
Interaction Type	physical association

Property	Details
Interacting Pfam domains	HECT~ubiquitin
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 875 Hs			1 229
+	Hs
		475003 UBE3A_HUMAN (1-875): 0: 1058: 100.00		UBB_HUMAN (1-229): 4.07e-98: 286: 100.00
+	Hs
		475652 UBE3A_HUMAN (1-875): 0: 1058: 100.00		UBC_HUMAN (1-153): 4.05e-53: 183: 99.35
+	Hs
		474953 NEDD4_HUMAN (46-873): 0: 622: 21.49		UBB_HUMAN (1-229): 4.07e-98: 286: 100.00
+	Hs
		125112 WWP2_HUMAN (291-873): 0: 589: 24.72		UBB_HUMAN (1-229): 4.07e-98: 286: 100.00
+	Hs
		475140 ITCH_HUMAN (325-873): 0: 579: 24.78		UBB_HUMAN (1-229): 4.07e-98: 286: 100.00
+	Hs
		475196 SMUF2_HUMAN (334-872): 0: 554: 24.79		UBB_HUMAN (1-229): 4.07e-98: 286: 100.00
+	Sc
		477293 RSP5_YEAST (310-873): 0: 554: 25.85		UBI4P_YEAST (1-228): 5.66e-90: 271: 96.05
+	Hs
		475470 NEDD4_HUMAN (46-873): 0: 622: 21.49		UBC_HUMAN (1-153): 4.05e-53: 183: 99.35
+	Rn
		1140970 Q5YB86_RAT (330-873): 0: 572: 25.09		UBC_RAT (1-181): 2.6e-61: 206: 96.13
+	Mm
		476846 HERC4_MOUSE (157-875): 0: 568: 27.46		UBC_MOUSE (1-181): 6.49e-62: 207: 96.13
+	Hs
		125113 WWP2_HUMAN (291-873): 0: 589: 24.72		UBC_HUMAN (1-153): 4.05e-53: 183: 99.35
+	Hs
		475785 HERC3_HUMAN (139-874): 0: 582: 26.85		UBC_HUMAN (1-153): 4.05e-53: 183: 99.35
+	Hs
		476205 ITCH_HUMAN (325-873): 0: 579: 24.78		UBC_HUMAN (1-153): 4.05e-53: 183: 99.35
+	Hs
		476229 NED4L_HUMAN (247-873): 0: 575: 22.52		UBC_HUMAN (1-153): 4.05e-53: 183: 99.35
+	Hs
		476350 WWP1_HUMAN (185-873): 0: 560: 22.22		UBC_HUMAN (1-153): 4.05e-53: 183: 99.35
+	Hs
		476403 SMUF2_HUMAN (334-872): 0: 554: 24.79		UBC_HUMAN (1-153): 4.05e-53: 183: 99.35
+	Hs
		125347 WWP2_HUMAN (291-873): 0: 589: 24.72		RS27A_HUMAN (153-228): 1.76e-44: 147: 100.00
+	Hs
		397834 NEDD4_HUMAN (46-873): 0: 622: 21.49		ISG15_HUMAN (3-154): 1.46e-26: 102: 32.26
+	Hs
		924156 WWP1_HUMAN (185-873): 0: 560: 22.22		RS27A_HUMAN (153-228): 1.76e-44: 147: 100.00
+	Hs
		397975 HERC3_HUMAN (139-874): 0: 582: 26.85		ISG15_HUMAN (3-154): 1.46e-26: 102: 32.26