HitPredict

Interactor 1: UBE3A (Q05086)
Ubiquitin-protein ligase E3A (EC 2.3.2.26) (E6AP ubiquitin-protein ligase) (HECT-type ubiquitin transferase E3A) (Human papillomavirus E6-associated protein) (Oncogenic protein-associated protein E6-AP) (Renal carcinoma antigen NY-REN-54)
Gene: UBE3A

Interactor 2: ESR2 (Q92731)
Estrogen receptor beta (ER-beta) (Nuclear receptor subfamily 3 group A member 2)
Gene: ESR2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.76	0.60	0.676

Property	Details
Experiments	33456993, 25408199, 17962381, 36109631
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0045944 - positive regulation of transcription by RNA polymerase II
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 875 Hs			1 530
+	Hs
		369460 UBE3A_HUMAN (1-875): 0: 1058: 100.00		ESR1_HUMAN (9-529): 3.58e-138: 413: 44.56
+	Hs
		377267 UBE3A_HUMAN (1-875): 0: 1058: 100.00		GCR_HUMAN (3-495): 1.12e-103: 330: 22.64
+	Hs
		487952 UBE3A_HUMAN (1-875): 0: 1058: 100.00		RARA_HUMAN (52-505): 3.54e-105: 324: 23.74
+	Hs
		414493 UBE3A_HUMAN (1-875): 0: 1058: 100.00		PRGR_HUMAN (149-459): 2.26e-41: 161: 32.82
+	Hs
		437637 UBE3A_HUMAN (1-875): 0: 1058: 100.00		MCR_HUMAN (141-408): 5.92e-38: 150: 34.03
+	Hs
		487361 UBE3A_HUMAN (1-875): 0: 1058: 100.00		ANDR_HUMAN (149-407): 8.1e-38: 150: 32.59
+	Hs
		1269572 WWP1_HUMAN (185-873): 0: 560: 22.22		ESR2_HUMAN (1-530): 2.38e-157: 460: 100.00
+	Hs
		1269872 HERC5_HUMAN (153-873): 1.77e-175: 536: 23.20		ESR2_HUMAN (1-530): 2.38e-157: 460: 100.00
+	Hs
		370480 SMUF1_HUMAN (405-872): 1.32e-175: 528: 27.04		ESR1_HUMAN (9-529): 3.58e-138: 413: 44.56
+	Hs
		377607 NED4L_HUMAN (247-873): 0: 575: 22.52		GCR_HUMAN (3-495): 1.12e-103: 330: 22.64
+	Hs
		500370 HACE1_HUMAN (241-869): 1.41e-177: 538: 23.75		RARB_HUMAN (49-529): 1.02e-113: 346: 23.92
+	Hs
		611504 SMUF2_HUMAN (334-872): 0: 554: 24.79		NR4A1_HUMAN (7-501): 3.18e-101: 318: 25.30
+	Hs
		530804 HACE1_HUMAN (241-869): 1.41e-177: 538: 23.75		RARG_HUMAN (68-525): 2.18e-107: 330: 24.18
+	Hs
		487995 HACE1_HUMAN (241-869): 1.41e-177: 538: 23.75		RARA_HUMAN (52-505): 3.54e-105: 324: 23.74
+	Hs
		377461 HERC6_HUMAN (151-872): 1.74e-172: 528: 24.09		GCR_HUMAN (3-495): 1.12e-103: 330: 22.64
+	Hs
		622846 HERC5_HUMAN (153-873): 1.77e-175: 536: 23.20		COT2_HUMAN (77-502): 2.24e-102: 316: 23.90
+	Hs
		414514 HERC4_HUMAN (157-875): 3.32e-179: 547: 27.46		PRGR_HUMAN (149-459): 2.26e-41: 161: 32.82
+	Hs
		1336130 SMUF1_HUMAN (405-872): 1.32e-175: 528: 27.04		NR2E1_HUMAN (149-408): 2.63e-35: 137: 31.82
+	Hs
		369911 HUWE1_HUMAN (523-874): 5.96e-53: 203: 33.97		ESR1_HUMAN (9-529): 3.58e-138: 413: 44.56
+	Hs
		487557 HUWE1_HUMAN (523-874): 5.96e-53: 203: 33.97		ANDR_HUMAN (149-407): 8.1e-38: 150: 32.59