HitPredict

Interactor 1: UBE3A (Q05086)
Ubiquitin-protein ligase E3A (EC 2.3.2.26) (E6AP ubiquitin-protein ligase) (HECT-type ubiquitin transferase E3A) (Human papillomavirus E6-associated protein) (Oncogenic protein-associated protein E6-AP) (Renal carcinoma antigen NY-REN-54)
Gene: UBE3A

Interactor 2: FAF2 (Q96CS3)
FAS-associated factor 2 (UBX domain-containing protein 3B) (UBX domain-containing protein 8)
Gene: FAF2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.73	0.60	0.664

Property	Details
Experiments	29263404, 35045253, 18775313
Identification Methods	enzymatic study, affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 875 Hs			1 445
+	Hs
		299360 UBE3A_HUMAN (1-875): 0: 1058: 100.00		UBXN7_HUMAN (1-441): 1.1e-116: 352: 16.34
+	Hs
		979287 UBE3A_HUMAN (1-875): 0: 1058: 100.00		UBXN1_HUMAN (295-439): 7.93e-19: 88.4: 16.36
+	Hs
		1287185 SMUF1_HUMAN (405-872): 1.32e-175: 528: 27.04		FAF2_HUMAN (1-445): 1.33e-143: 419: 100.00
+	Hs
		299472 SMUF1_HUMAN (405-872): 1.32e-175: 528: 27.04		UBXN7_HUMAN (1-441): 1.1e-116: 352: 16.34
+	Hs
		125790 WWP2_HUMAN (291-873): 0: 589: 24.72		FAF1_HUMAN (112-440): 5.62e-83: 269: 24.79
+	Sc
		765386 RSP5_YEAST (310-873): 0: 554: 25.85		UBX2_YEAST (9-430): 9.04e-66: 222: 16.38
+	Sc
		765431 RSP5_YEAST (310-873): 0: 554: 25.85		UBX3_YEAST (121-444): 1.7e-59: 203: 22.81
+	Hs
		1192165 HUWE1_HUMAN (523-874): 5.96e-53: 203: 33.97		FAF2_HUMAN (1-445): 1.33e-143: 419: 100.00
+	Hs
		1072704 UBE3C_HUMAN (453-872): 2.23e-52: 200: 32.27		FAF2_HUMAN (1-445): 1.33e-143: 419: 100.00
+	Hs
		979321 HUWE1_HUMAN (523-874): 5.96e-53: 203: 33.97		UBXN1_HUMAN (295-439): 7.93e-19: 88.4: 16.36