HitPredict

Interactor 1: UBE3A (Q05086)
Ubiquitin-protein ligase E3A (EC 2.3.2.26) (E6AP ubiquitin-protein ligase) (HECT-type ubiquitin transferase E3A) (Human papillomavirus E6-associated protein) (Oncogenic protein-associated protein E6-AP) (Renal carcinoma antigen NY-REN-54)
Gene: UBE3A

Interactor 2: RING2 (Q99496)
E3 ubiquitin-protein ligase RING2 (EC 2.3.2.27) (Huntingtin-interacting protein 2-interacting protein 3) (HIP2-interacting protein 3) (Protein DinG) (RING finger protein 1B) (RING1b) (RING finger protein 2) (RING finger protein BAP-1) (RING-type E3 ubiquitin transferase RING2)
Gene: RNF2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.81	0.60	0.700

Property	Details
Experiments	20351251, 26216987, 30040487, 33542309
Identification Methods	affinity chromatography technology, enzymatic study, pull down
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0061630 - ubiquitin protein ligase activity
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 875 Hs			1 336
+	Hs
		717739 UBE3A_HUMAN (1-875): 0: 1058: 100.00		BMI1_HUMAN (34-332): 4.13e-45: 158: 15.51
+	Hs
		983223 UBE3A_HUMAN (1-875): 0: 1058: 100.00		BARD1_HUMAN (1-291): 1.2e-38: 147: 12.42
+	Hs
		749407 UBE3A_HUMAN (1-875): 0: 1058: 100.00		BRCA1_HUMAN (36-214): 1.15e-33: 133: 25.79
+	Hs
		125664 WWP2_HUMAN (291-873): 0: 589: 24.72		RING2_HUMAN (1-336): 4.99e-112: 330: 100.00
+	Hs
		125186 WWP2_HUMAN (291-873): 0: 589: 24.72		BMI1_HUMAN (34-332): 4.13e-45: 158: 15.51
+	Hs
		1305975 HERC5_HUMAN (153-873): 1.77e-175: 536: 23.20		BARD1_HUMAN (1-291): 1.2e-38: 147: 12.42
+	Hs
		749630 HUWE1_HUMAN (523-874): 5.96e-53: 203: 33.97		BRCA1_HUMAN (36-214): 1.15e-33: 133: 25.79
+	Hs
		749520 UBE3C_HUMAN (453-872): 2.23e-52: 200: 32.27		BRCA1_HUMAN (36-214): 1.15e-33: 133: 25.79