HitPredict

Interactor 1: UBE3A (Q05086)
Ubiquitin-protein ligase E3A (EC 2.3.2.26) (E6AP ubiquitin-protein ligase) (HECT-type ubiquitin transferase E3A) (Human papillomavirus E6-associated protein) (Oncogenic protein-associated protein E6-AP) (Renal carcinoma antigen NY-REN-54)
Gene: UBE3A

Interactor 2: UBQL2 (Q9UHD9)
Ubiquilin-2 (Chap1) (DSK2 homolog) (Protein linking IAP with cytoskeleton 2) (PLIC-2) (hPLIC-2) (Ubiquitin-like product Chap1/Dsk2)
Gene: UBQLN2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.83	1.00	0.914

Property	Details
Experiments	33277362, 36827983, 10983987, 29426014
Identification Methods	affinity chromatography technology, two hybrid, pull down, two hybrid prey pooling approach, two hybrid array
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	HECT~ubiquitin
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol GO:0006511 - ubiquitin-dependent protein catabolic process
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 875 Hs			1 624
+	Hs
		983269 UBE3A_HUMAN (1-875): 0: 1058: 100.00		UBQL1_HUMAN (1-624): 8.68e-147: 439: 71.52
+	Hs
		983150 UBE3A_HUMAN (1-875): 0: 1058: 100.00		DDI2_HUMAN (43-314): 6.26e-52: 185: 14.59
+	Hs
		1065054 HERC3_HUMAN (139-874): 0: 582: 26.85		UBQL2_HUMAN (1-624): 1.19e-153: 458: 100.00
+	Hs
		125787 WWP2_HUMAN (291-873): 0: 589: 24.72		UBQL1_HUMAN (1-624): 8.68e-147: 439: 71.52
+	Hs
		1065056 HERC3_HUMAN (139-874): 0: 582: 26.85		UBQL1_HUMAN (1-624): 8.68e-147: 439: 71.52
+	Hs
		1218013 HERC6_HUMAN (151-872): 1.74e-172: 528: 24.09		UBQL2_HUMAN (1-624): 1.19e-153: 458: 100.00
+	Hs
		1336106 SMUF1_HUMAN (405-872): 1.32e-175: 528: 27.04		UBQL2_HUMAN (1-624): 1.19e-153: 458: 100.00
+	Hs
		1355829 HERC5_HUMAN (153-873): 1.77e-175: 536: 23.20		UBQL1_HUMAN (1-624): 8.68e-147: 439: 71.52
+	Hs
		125739 WWP2_HUMAN (291-873): 0: 589: 24.72		UBQL4_HUMAN (22-624): 2.17e-124: 382: 54.55
+	Hs
		1336119 SMUF1_HUMAN (405-872): 1.32e-175: 528: 27.04		UBQL1_HUMAN (1-624): 8.68e-147: 439: 71.52
+	Hs
		125225 WWP2_HUMAN (291-873): 0: 589: 24.72		BAG6_HUMAN (21-580): 4.44e-53: 198: 15.23
+	Hs
		924302 HERC3_HUMAN (139-874): 0: 582: 26.85		RL40_HUMAN (33-112): 7.49e-34: 127: 30.86
+	Hs
		125347 WWP2_HUMAN (291-873): 0: 589: 24.72		RS27A_HUMAN (33-119): 4.49e-24: 100: 27.27
+	Hs
		924414 SMUF2_HUMAN (334-872): 0: 554: 24.79		RL40_HUMAN (33-112): 7.49e-34: 127: 30.86
+	Hs
		924156 WWP1_HUMAN (185-873): 0: 560: 22.22		RS27A_HUMAN (33-119): 4.49e-24: 100: 27.27
+	Hs
		803611 HUWE1_HUMAN (523-874): 5.96e-53: 203: 33.97		BAG6_HUMAN (21-580): 4.44e-53: 198: 15.23
+	Hs
		1072687 UBE3C_HUMAN (453-872): 2.23e-52: 200: 32.27		DDI2_HUMAN (43-314): 6.26e-52: 185: 14.59
+	Hs
		924336 HUWE1_HUMAN (523-874): 5.96e-53: 203: 33.97		RL40_HUMAN (33-112): 7.49e-34: 127: 30.86
+	Mm
		924239 HUWE1_MOUSE (523-874): 7.59e-53: 203: 33.97		RS27A_MOUSE (33-119): 5.82e-13: 68.8: 27.27