HitPredict

Interactor 1: UBE3A (Q05086)
Ubiquitin-protein ligase E3A (EC 2.3.2.26) (E6AP ubiquitin-protein ligase) (HECT-type ubiquitin transferase E3A) (Human papillomavirus E6-associated protein) (Oncogenic protein-associated protein E6-AP) (Renal carcinoma antigen NY-REN-54)
Gene: UBE3A

Interactor 2: UCHL5 (Q9Y5K5)
Ubiquitin carboxyl-terminal hydrolase isozyme L5 (UCH-L5) (EC 3.4.19.12) (Ubiquitin C-terminal hydrolase UCH37) (Ubiquitin thioesterase L5)
Gene: UCHL5

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.92	0.60	0.747

Property	Details
Experiments	24743594, 22645313, 29426014, 26186194, 28514442, 33961781, 34761751
Identification Methods	enzymatic study, affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol GO:0006511 - ubiquitin-dependent protein catabolic process
Homologous interactions	4

Homologous interactions

Color coding for hit scores

	1 875 Hs			1 329
+	Hs
		1192286 HUWE1_HUMAN (523-874): 5.96e-53: 203: 33.97		UCHL5_HUMAN (1-329): 1.1e-175: 491: 100.00
+	Hs
		1072738 UBE3C_HUMAN (453-872): 2.23e-52: 200: 32.27		UCHL5_HUMAN (1-329): 1.1e-175: 491: 100.00
+	Hs
		1267153 WWP1_HUMAN (185-873): 0: 560: 22.22		BAP1_HUMAN (246-315): 2.11e-16: 82: 34.29
+	Hs
		1192140 HUWE1_HUMAN (523-874): 5.96e-53: 203: 33.97		BAP1_HUMAN (246-315): 2.11e-16: 82: 34.29