HitPredict

Interactor 1: DYN1 (Q05193)
Dynamin-1 (EC 3.6.5.5) (Dynamin) (Dynamin I)
Gene: DNM1

Interactor 2: ITSN1 (Q15811)
Intersectin-1 (SH3 domain-containing protein 1A) (SH3P17)
Gene: ITSN1

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.68	1.00	0.825

Property	Details
Experiments	15834155, 18539136
Identification Methods	pull down, affinity chromatography technology, surface plasmon resonance
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	PH~RhoGEF, PH~SH3_1, PH~SH3_9
Common GO terms	GO:0005737 - cytoplasm GO:0005886 - plasma membrane GO:0005905 - clathrin-coated pit
Homologous interactions	13

Homologous interactions

Color coding for hit scores

	1 864 Hs			1 1721
+	Mm
		760469 DYN1_MOUSE (1-845): 0: 1081: 99.65		ITSN1_MOUSE (1-1721): 0: 864: 94.54
+	Rn
		599413 DYN1_RAT (1-864): 0: 1081: 98.03		ITSN1_RAT (1-1721): 0: 853: 92.27
+	Hs
		840702 DYN2_HUMAN (1-860): 0: 1021: 78.91		ITSN1_HUMAN (1-1721): 0: 897: 100.00
+	Mm
		760488 DYN2_MOUSE (1-860): 0: 1022: 79.13		ITSN1_MOUSE (1-1721): 0: 864: 94.54
+	Hs
		840840 DYN2_HUMAN (1-860): 0: 1021: 78.91		ITSN2_HUMAN (1-1720): 0: 723: 54.73
+	Ce
		760500 DYN1_CAEEL (3-805): 0: 916: 64.18		VAV_CAEEL (1160-1566): 7.98e-66: 245: 16.74
+	Hs
		557664 DYN1_HUMAN (1-864): 0: 1087: 100.00		NCK1_HUMAN (895-1055): 6.44e-09: 62: 27.75
+	Hs
		787872 DYN2_HUMAN (1-860): 0: 1021: 78.91		EPS15_HUMAN (529-913): 1.04e-10: 68.9: 12.69
+	Hs
		840719 DYN2_HUMAN (1-860): 0: 1021: 78.91		SH319_HUMAN (1079-1218): 3.12e-09: 63.9: 28.57
+	Dm
		112570 DYN_DROME (6-859): 0: 963: 65.41		M9ND00_DROME (713-1252): 3.91e-15: 83.6: 12.73
+	Dm
		247616 DYN_DROME (6-859): 0: 963: 65.41		O61618_DROME (709-1252): 1.69e-14: 81.7: 12.68
+	Dm
		91155 DYN_DROME (6-859): 0: 963: 65.41		E3CTP7_DROME (25-165): 8.27e-11: 69.2: 22.37
+	Ce
		760510 DYN1_CAEEL (3-805): 0: 916: 64.18		Q9U2T9_CAEEL (708-1241): 6.47e-10: 66.6: 11.25