HitPredict

Interactor 1: DYN1 (Q05193)
Dynamin-1 (EC 3.6.5.5) (Dynamin) (Dynamin I)
Gene: DNM1

Interactor 2: SH3K1 (Q96B97)
SH3 domain-containing kinase-binding protein 1 (CD2-binding protein 3) (CD2BP3) (Cbl-interacting protein of 85 kDa) (Human Src family kinase-binding protein 1) (HSB-1)
Gene: SH3KBP1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	19531213
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PH~SH3_9
Common GO terms	GO:0005737 - cytoplasm GO:0005886 - plasma membrane GO:0006897 - endocytosis GO:0030139 - endocytic vesicle GO:0045202 - synapse
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 864 Hs			1 665
+	Mm
		760462 DYN1_MOUSE (1-845): 0: 1081: 99.65		SH3K1_MOUSE (1-665): 4.53e-118: 370: 87.59
+	Mm
		760481 DYN2_MOUSE (1-860): 0: 1022: 79.13		SH3K1_MOUSE (1-665): 4.53e-118: 370: 87.59
+	Hs
		557664 DYN1_HUMAN (1-864): 0: 1087: 100.00		NCK1_HUMAN (104-421): 1.23e-32: 131: 16.81
+	Hs
		924499 DYN1_HUMAN (1-864): 0: 1087: 100.00		GRB2_HUMAN (2-158): 6.97e-33: 128: 19.91
+	Rn
		599402 DYN1_RAT (1-864): 0: 1081: 98.03		GRB2_RAT (2-158): 6.97e-33: 128: 19.91
+	Mm
		760450 DYN1_MOUSE (1-845): 0: 1081: 99.65		GRB2_MOUSE (2-158): 6.83e-33: 128: 19.91
+	Hs
		983379 DYN1_HUMAN (1-864): 0: 1087: 100.00		ITSN1_HUMAN (68-454): 2.48e-21: 101: 14.01
+	Mm
		760469 DYN1_MOUSE (1-845): 0: 1081: 99.65		ITSN1_MOUSE (120-519): 1.9e-19: 95.5: 14.11
+	Rn
		599413 DYN1_RAT (1-864): 0: 1081: 98.03		ITSN1_RAT (120-519): 6.47e-19: 94: 14.11
+	Hs
		983387 DYN1_HUMAN (1-864): 0: 1087: 100.00		DNMBP_HUMAN (104-607): 3.03e-16: 85.1: 15.82
+	Hs
		209034 DYN1_HUMAN (1-864): 0: 1087: 100.00		NCK2_HUMAN (184-428): 2.06e-16: 83.6: 12.77
+	Mm
		223006 DYN1_MOUSE (1-845): 0: 1081: 99.65		NCK2_MOUSE (184-428): 6.56e-15: 78.9: 12.41
+	Mm
		760474 DYN2_MOUSE (1-860): 0: 1022: 79.13		GRB2_MOUSE (2-158): 6.83e-33: 128: 19.91
+	Rn
		192739 DYN1_RAT (1-864): 0: 1081: 98.03		SRBS2_RAT (3-155): 3.11e-11: 68.9: 30.25
+	Hs
		840663 DYN2_HUMAN (1-860): 0: 1021: 78.91		GRB2_HUMAN (2-158): 6.97e-33: 128: 19.91
+	Hs
		840702 DYN2_HUMAN (1-860): 0: 1021: 78.91		ITSN1_HUMAN (68-454): 2.48e-21: 101: 14.01
+	Mm
		760488 DYN2_MOUSE (1-860): 0: 1022: 79.13		ITSN1_MOUSE (120-519): 1.9e-19: 95.5: 14.11
+	Hs
		275181 DYN2_HUMAN (1-860): 0: 1021: 78.91		GRAP2_HUMAN (1-56): 2.18e-17: 85.8: 32.14
+	Rn
		192740 DYN2_RAT (1-860): 0: 1021: 79.02		SRBS2_RAT (3-155): 3.11e-11: 68.9: 30.25
+	Hs
		840719 DYN2_HUMAN (1-860): 0: 1021: 78.91		SH319_HUMAN (164-469): 4.12e-09: 61.9: 13.31