HitPredict

Interactor 1: DYN1 (Q05193)
Dynamin-1 (EC 3.6.5.5) (Dynamin) (Dynamin I)
Gene: DNM1

Interactor 2: SH3G1 (Q99961)
Endophilin-A2 (EEN fusion partner of MLL) (Endophilin-2) (Extra eleven-nineteen leukemia fusion gene protein) (EEN) (SH3 domain protein 2B) (SH3 domain-containing GRB2-like protein 1)
Gene: SH3GL1

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.60	1.00	0.778

Property	Details
Experiments	10764144, 10542231
Identification Methods	pull down, peptide array
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	PH~SH3_1
Common GO terms	GO:0005737 - cytoplasm GO:0042995 - cell projection GO:0098793 - presynapse GO:0098978 - glutamatergic synapse
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 864 Hs			1 368
+	Mm
		760453 DYN1_MOUSE (1-845): 0: 1081: 99.65		SH3G1_MOUSE (1-368): 7.42e-89: 273: 94.02
+	Rn
		193636 DYN1_RAT (1-864): 0: 1081: 98.03		SH3G1_RAT (1-368): 5.26e-88: 271: 92.94
+	Mm
		760455 DYN1_MOUSE (1-845): 0: 1081: 99.65		SH3G3_MOUSE (1-367): 8.72e-87: 267: 63.76
+	Hs
		983405 DYN1_HUMAN (1-864): 0: 1087: 100.00		SH3G2_HUMAN (1-368): 1.98e-84: 261: 68.75
+	Rn
		192351 DYN1_RAT (1-864): 0: 1081: 98.03		SH3G2_RAT (1-368): 2.02e-84: 261: 68.48
+	Rn
		192355 DYN1_RAT (1-864): 0: 1081: 98.03		SH3G3_RAT (1-368): 2.22e-84: 261: 62.77
+	Mm
		760454 DYN1_MOUSE (1-845): 0: 1081: 99.65		SH3G2_MOUSE (1-368): 8.98e-84: 260: 69.02
+	Mm
		760467 DYN1_MOUSE (1-845): 0: 1081: 99.65		SHLB1_MOUSE (10-363): 3.6e-69: 223: 25.00
+	Hs
		983392 DYN1_HUMAN (1-864): 0: 1087: 100.00		NOSTN_HUMAN (5-364): 1.09e-39: 149: 17.34
+	Hs
		983406 DYN1_HUMAN (1-864): 0: 1087: 100.00		PACN1_HUMAN (16-363): 9.35e-37: 139: 14.89
+	Hs
		983417 DYN1_HUMAN (1-864): 0: 1087: 100.00		PACN2_HUMAN (16-364): 1.92e-34: 134: 14.97
+	Rn
		599414 DYN1_RAT (1-864): 0: 1081: 98.03		PACN1_RAT (16-363): 7.8e-36: 137: 14.61
+	Mm
		760451 DYN1_MOUSE (1-845): 0: 1081: 99.65		PACN1_MOUSE (16-363): 2.86e-35: 135: 14.61
+	Mm
		760473 DYN2_MOUSE (1-860): 0: 1022: 79.13		SRC8_MOUSE (85-362): 7.3e-38: 144: 13.62
+	Mm
		760475 DYN2_MOUSE (1-860): 0: 1022: 79.13		PACN1_MOUSE (16-363): 2.86e-35: 135: 14.61
+	Hs
		924499 DYN1_HUMAN (1-864): 0: 1087: 100.00		GRB2_HUMAN (311-367): 1.59e-11: 65.2: 41.38
+	Rn
		192739 DYN1_RAT (1-864): 0: 1081: 98.03		SRBS2_RAT (264-363): 2.11e-12: 70.5: 22.55
+	Rn
		599402 DYN1_RAT (1-864): 0: 1081: 98.03		GRB2_RAT (311-367): 1.59e-11: 65.2: 41.38
+	Mm
		760450 DYN1_MOUSE (1-845): 0: 1081: 99.65		GRB2_MOUSE (311-367): 1.59e-11: 65.2: 41.38
+	Mm
		760474 DYN2_MOUSE (1-860): 0: 1022: 79.13		GRB2_MOUSE (311-367): 1.59e-11: 65.2: 41.38